Pinheiro Sergio Veloso Brant, Dias Raphael Figuiredo, Fabiano Rafaela Cabral Gonçalves, Araujo Stanley de Almeida, Silva Ana Cristina Simões E
Universidade Federal de Minas Gerais, Hospital das Clínicas, Unidade de Nefrologia Pediátrica, Belo Horizonte, MG, Brasil.
J Bras Nefrol. 2019 Apr-Jun;41(2):252-265. doi: 10.1590/2175-8239-JBN-2018-0097. Epub 2018 Nov 14.
Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations seen in individuals with systemic lupus erythematosus (SLE). LN is more frequent and severe in pediatric patients and has been associated with higher morbidity and mortality rates. This narrative review aimed to describe the general aspects of LN and its particularities when affecting children and adolescents, while focusing on the disease's etiopathogenesis, clinical manifestations, renal tissue alterations, and treatment options.
狼疮性肾炎(LN)累及肾脏是系统性红斑狼疮(SLE)患者最严重的临床表现之一。LN在儿科患者中更为常见且严重,与更高的发病率和死亡率相关。本叙述性综述旨在描述LN的一般情况及其在影响儿童和青少年时的特殊性,同时重点关注该疾病的病因发病机制、临床表现、肾组织改变和治疗选择。