Katz L A, Cobbol C
Nephrology Section, V.A. Medical Center, New York, NY 10010.
Am J Hypertens. 1988 Jul;1(3 Pt 3):224S-226S. doi: 10.1093/ajh/1.3.224s.
Twenty-four black men with mild to moderate essential hypertension were enrolled in an open-label trial comparing the efficacy of two doses of Capozide (captopril and hydrochlorothiazide). All antihypertensive drugs were discontinued and patients then received placebo for 2 weeks. Twenty-two patients, mean age 59.1 +/- 14.3 years, with sitting diastolic blood pressure (BP) 92 to 110 mm Hg, entered the 6-week active-drug phase. Eleven patients (Group A) were randomized to Capozide 25/15 and 11 (Group B) to Capozide 50/15. Baseline mean BPs were 151.0/100.7 mm Hg in Group A and 153.1/100.7 mm Hg in Group B. At week 6, mean BPs were 128.7/84.4 mm Hg in Group A and 126.8/82.7 mm Hg in Group B. Uric acid, blood urea nitrogen and creatinine levels rose slightly in both groups. There were no adverse events. Eighteen patients had normal BPs at study completion. Twice-daily Capozide treatment is effective and well tolerated in blacks; patients responded equally well to both doses.
24名患有轻度至中度原发性高血压的黑人男性参与了一项开放标签试验，比较两种剂量的卡托普利氢氯噻嗪片（卡托普利和氢氯噻嗪）的疗效。所有抗高血压药物均停用，然后患者接受2周的安慰剂治疗。22名患者，平均年龄59.1±14.3岁，坐位舒张压（BP）为92至110毫米汞柱，进入为期6周的活性药物治疗阶段。11名患者（A组）被随机分配至服用25/15剂量的卡托普利氢氯噻嗪片，11名（B组）被随机分配至服用50/15剂量的卡托普利氢氯噻嗪片。A组的基线平均血压为151.0/100.7毫米汞柱，B组为153.1/100.7毫米汞柱。在第6周时，A组的平均血压为128.7/84.4毫米汞柱，B组为126.8/82.7毫米汞柱。两组的尿酸、血尿素氮和肌酐水平均略有升高。未出现不良事件。18名患者在研究结束时血压正常。每日两次服用卡托普利氢氯噻嗪片对黑人有效且耐受性良好；患者对两种剂量的反应同样良好。
