Clementy J, Schwebig A, Mazaud C, Justal A, Bricaud H
Postgrad Med J. 1986;62 Suppl 1:132-4.
A comparative study was made of the effects of a new therapeutic agent consisting of 50 mg captopril and 25 mg hydrochlorothiazide (Capozide) with an already existing agent Moduretic (50 mg hydrochlorothiazide and 5 mg amiloride). In the Capozide group (32 patients), 20 achieved normal blood pressure, 8 responded but were not brought under control, and 3 were non-responders. In the Moduretic group (31 patients), 17 achieved normal blood pressure, 10 were partially controlled and 4 were non-responders. Moduretic appeared to be most effective in patients previously untreated or who had been taking only one drug, while Capozide controlled patients who had been taking 1 or 2 antihypertensive drugs which had been either ineffective or poorly tolerated. The long-acting effect of a single dose of Capozide was demonstrated by blood pressure measurements taken at least 10 hours later. Both drugs were generally well tolerated and no significant changes were observed in the laboratory measurements. The combination of an angiotensin converting enzyme inhibitor with a diuretic proved more effective than single agents in lowering raised blood pressure. We therefore conclude that Capozide is an effective alternative to traditional medication in the treatment of moderate hypertension.
对一种由50毫克卡托普利和25毫克氢氯噻嗪组成的新型治疗药物（复方卡托普利）与已有的药物莫顿利尿片（50毫克氢氯噻嗪和5毫克阿米洛利）的效果进行了一项对比研究。在复方卡托普利组（32例患者）中，20例血压恢复正常，8例有反应但未得到控制，3例无反应。在莫顿利尿片组（31例患者）中，17例血压恢复正常，10例部分得到控制，4例无反应。莫顿利尿片似乎对既往未治疗或仅服用一种药物的患者最有效，而复方卡托普利对服用过1种或2种无效或耐受性差的抗高血压药物的患者有效。单次服用复方卡托普利的长效作用通过至少10小时后测量血压得以证实。两种药物一般耐受性良好，实验室检查未观察到显著变化。血管紧张素转换酶抑制剂与利尿剂联合使用在降低升高的血压方面比单一药物更有效。因此，我们得出结论，复方卡托普利是治疗中度高血压的传统药物的有效替代品。
