University of Massachusetts, Worcester, Massachusetts, USA.
University of Massachusetts, Worcester, Massachusetts, USA.
J Invest Dermatol. 2018 Dec;138(12):2505-2506. doi: 10.1016/j.jid.2018.08.003.
HSP70i is secreted by stressed melanocytes, is associated with human vitiligo lesions, and functionally contributes to a mouse model of vitiligo. Henning et al. report that treatment with a modified version of the protein reversed depigmentation in Sinclair swine, a useful animal model of vitiligo. These studies provide the rationale for testing in human studies.
HSP70i 由受应激的黑素细胞分泌，与人类白癜风病变有关，并对白癜风的小鼠模型具有功能贡献。Henning 等人报告称，该蛋白的改良版本的治疗逆转了 Sinclair 猪的色素脱失，这是一种有用的白癜风动物模型。这些研究为在人类研究中进行测试提供了依据。
