Selektor L Ia, Ermishkin V V, Revenko S V, Khaiutin V M
Biull Eksp Biol Med. 1988 Aug;106(8):183-7.
Intraarterial acetylcholine (Ach) and acetyl-beta-methylcholine (metacholine, Mch) excite feline high-threshold C-fiber mechanosensitive cutaneous sensory units (SU) in a different way. Ach in noxious (algogenic for humans) concentrations of 10 micrograms/ml and more induces a high-frequency discharge, with mean frequency of impulses at its peak being 4-12 Hz. This discharge seems to result from activation of N-cholinoreceptors because non-noxious and nonalgogenic M-agonist Mch as well as Ach in subnoxious concentrations induce in SU only a low-frequency discharge with a mean frequency of impulses 0.5-3.5 Hz. The data are discussed in connection with nociception and tissue chemoreception.
动脉内注射乙酰胆碱（Ach）和乙酰-β-甲基胆碱（醋甲胆碱，Mch）以不同方式兴奋猫的高阈值C纤维机械敏感皮肤感觉单位（SU）。浓度为10微克/毫升及以上的有害（对人类有致痛作用）浓度的Ach会诱发高频放电，其峰值时的平均冲动频率为4 - 12赫兹。这种放电似乎是由N - 胆碱能受体的激活引起的，因为无害且无致痛作用的M - 激动剂Mch以及亚有害浓度的Ach在SU中仅诱发平均冲动频率为0.5 - 3.5赫兹的低频放电。结合伤害感受和组织化学感受对这些数据进行了讨论。
