天然产物在肾脏病防治中的应用。
Natural products for the prevention and treatment of kidney disease.
机构信息
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China.
School of Pharmacy, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang 310053, China.
出版信息
Phytomedicine. 2018 Nov 15;50:50-60. doi: 10.1016/j.phymed.2018.09.182. Epub 2018 Sep 17.
BACKGROUND
Chronic kidney disease (CKD) is one of the common causes resulting in a high morbidity and mortality. Renal fibrosis is the main pathological features of CKD. Natural products have begun to gain widely popularity worldwide for promoting healthcare and preventing CKD, and have been used as a conventional or complementary therapy for CKD treatment.
PURPOSE
The present paper reviewed the therapeutic effects of natural products on CKD and revealed the molecular mechanisms of their anti-fibrosis.
METHODS
All the available information on natural products against renal fibrosis was collected via a library and electronic search (using Web of Science, Pubmed, ScienceDirect, Splinker, etc.).
RESULTS
Accumulated evidence demonstrated that natural products exhibited the beneficial effects for CKD treatment and against renal fibrosis. This review presents an overview of the molecular mechanism of CKD and natural products against renal fibrosis, followed by an in-depth discussion of their molecular mechanism of natural products including isolated compounds and crude extracts against renal fibrosis in vitro and in vivo. A number of isolated compounds have been confirmed to retard renal fibrosis.
CONCLUSION
The review provides comprehensive insights into pathophysiological mechanisms of CKD and natural products against renal fibrosis. Particular challenges are presented and placed within the context of future applications of natural products against renal fibrosis.
背景
慢性肾脏病（CKD）是导致高发病率和死亡率的常见原因之一。肾纤维化是 CKD 的主要病理特征。天然产物已开始在全球范围内广泛流行，用于促进健康和预防 CKD，并已被用作 CKD 治疗的常规或补充疗法。
目的
本文综述了天然产物对 CKD 的治疗作用，并揭示了其抗纤维化的分子机制。
方法
通过图书馆和电子搜索（使用 Web of Science、Pubmed、ScienceDirect、Splinker 等）收集了所有关于天然产物抗肾纤维化的可用信息。
结果
大量证据表明，天然产物对 CKD 的治疗和抗肾纤维化具有有益作用。本综述概述了 CKD 的分子机制和天然产物对肾纤维化的作用，随后深入讨论了天然产物，包括体外和体内的分离化合物和粗提物，对肾纤维化的分子机制。已经证实许多分离化合物可延缓肾纤维化。
结论
本综述全面深入地探讨了 CKD 的病理生理机制和天然产物对肾纤维化的作用。特别提出了一些挑战，并将其置于未来天然产物抗肾纤维化应用的背景下。
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