载脂蛋白 A1 基因 rs670 变异体在肥胖人群接受高脂肪和低脂肪低热量饮食后的代谢反应中的作用。
Role of rs670 variant of APOA1 gene on metabolic response after a high fat vs. a low fat hypocaloric diets in obese human subjects.
机构信息
Endocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Endocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
出版信息
J Diabetes Complications. 2019 Mar;33(3):249-254. doi: 10.1016/j.jdiacomp.2018.10.015. Epub 2018 Nov 3.
BACKGROUND & AIMS: A common G-to-A transition located 75 base pairs upstream (rs670) from transcription start site of the APOA1 gene has been related with some metabolic parameters. Our aim was to analyze the effects of rs670 APOA1 gene polymorphism on lipid profile and metabolic changes after two different hypocaloric diets.
METHODS
282 obese subjects were randomly allocated during 12 weeks (Diet HF - high fat diet vs. Diet LF - low fat diet). Anthropometric and biochemical status were evaluated.
RESULTS
Body mass index, weight, fat mass, waist circumference, systolic blood pressure, leptin levels and waist circumference decreased in all patients in average after both diets. In A allele carriers after 12 weeks with both diets, insulin levels (Delta diet HF: -5.3 + 1.2 UI/L; P = 0.02 and Delta diet LF: -5.8 + 1.3 UI/L; P = 0.02) and HOMA-IR (Delta diet HF: -2.9 + 0.8 units; P = 0.01 and Delta diet LF: -2.2 + 0.9 units; P = 0.03) improved in a significant way. With the low fat diet, A allele carriers showed a statistical improvement in HDL-cholesterol levels (Delta: 4 + 1 mg/dl; P = 0.03).
CONCLUSIONS
Our study showed the association of rs670 ApoA1 polymorphism with a decrease of insulin resistance induced by both diets and provided additional evidence on HDL-cholesterol increase after a LF hypocaloric diet in A allele carriers.
背景与目的
位于载脂蛋白 A1 基因转录起始位点上游 75 个碱基对处的常见 G 到 A 转换（rs670）与一些代谢参数有关。我们的目的是分析 rs670 载脂蛋白 A1 基因多态性对两种不同低热量饮食后血脂谱和代谢变化的影响。
方法
282 名肥胖受试者在 12 周内（高脂饮食组 vs. 低脂饮食组）随机分配。评估了人体测量和生化状态。
结果
所有患者在两种饮食后平均体重指数、体重、体脂量、腰围、收缩压、瘦素水平和腰围均下降。在两种饮食后 12 周的 A 等位基因携带者中，胰岛素水平（饮食 HF 组的变化：-5.3±1.2 UI/L；P=0.02 和饮食 LF 组的变化：-5.8±1.3 UI/L；P=0.02）和 HOMA-IR（饮食 HF 组的变化：-2.9±0.8 单位；P=0.01 和饮食 LF 组的变化：-2.2±0.9 单位；P=0.03）均显著改善。在低脂饮食组中，A 等位基因携带者的 HDL-胆固醇水平（变化：4+1mg/dl；P=0.03）有统计学意义的改善。
结论
我们的研究表明，rs670 载脂蛋白 A1 多态性与两种饮食引起的胰岛素抵抗降低有关，并为低脂低热量饮食后 A 等位基因携带者 HDL-胆固醇升高提供了额外的证据。
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