Mongold J J, Cros G H, Michel A, McNeill J H, Serrano J J
Laboratoire de pharmacodynamie, Faculté de pharmacie, Montpellier, France.
Can J Physiol Pharmacol. 1988 May;66(5):660-2. doi: 10.1139/y88-103.
Contractile responses to carbachol of tracheal segments isolated (i) from rats made diabetic 4 months prior by a single intravenous injection (50 mg/kg) of streptozotocin (group B), and (ii) from diabetic rats that had been treated during the same period with a daily dose (2-4 U/animal) of long-acting insulin (group C) were compared with the contractile responses of trachea isolated from age-matched control animals (group A). Tracheal segments from group B were significantly more responsive to carbachol than those from group A or C at low, but not at high carbachol concentrations. Carbachol pD2 values were higher in group B (6.85 +/- 0.05) than in groups A (6.46 +/- 0.07) or C (6.37 +/- 0.06), but were not significantly different between groups A and C. These data indicate that diabetes induces a supersensitivity to carbachol in airway smooth muscles, possibly related to a diabetes-induced vagal autonomic neuropathy.
将从以下两组大鼠分离出的气管段对卡巴胆碱的收缩反应，与从年龄匹配的对照动物（A组）分离出的气管的收缩反应进行比较：（i）4个月前通过单次静脉注射链脲佐菌素（50 mg/kg）制成糖尿病大鼠的气管段（B组），以及（ii）同期每日给予长效胰岛素（2 - 4 U/动物）治疗的糖尿病大鼠的气管段（C组）。在低卡巴胆碱浓度下，B组气管段对卡巴胆碱的反应明显高于A组或C组，但在高卡巴胆碱浓度下并非如此。B组卡巴胆碱的pD2值（6.85 +/- 0.05）高于A组（6.46 +/- 0.07）或C组（6.37 +/- 0.06），但A组和C组之间无显著差异。这些数据表明，糖尿病会导致气道平滑肌对卡巴胆碱超敏，这可能与糖尿病诱发的迷走神经自主神经病变有关。
