a Neurology Department , Namık Kemal University School of Medicine , Tekirdag , Turkey.
b Public Health Department , Namık Kemal University School of Medicine , Tekirdag , Turkey.
Amyotroph Lateral Scler Frontotemporal Degener. 2019 Feb;20(1-2):100-106. doi: 10.1080/21678421.2018.1525403. Epub 2018 Nov 23.
The aim of the study was to investigate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in Thrace, Turkey in a five-year time period (2006-2010).
Study population included residents of three provinces (Edirne, Tekirdag, Kırklareli) in the Thrace region. Cases were ascertained from all of the neurologic centers and hospitals of these provinces. Demographic and clinical information was collected for each patient. Newly diagnosed ALS patients who are fulfilling the El Escorial revised diagnostic criteria were enrolled into the study.
We identified a total of 145 patients (93 males, 52 females). The mean age at diagnosis was 57.0 ± 13.6. According to El Escorial criteria, 60.0% of the cases were definite ALS, 24.8% were probable, and 15.2% were possible ALS. Thirty-two cases were bulbar (22.1%), 113 cases (77.9%) were spinal onset. Mean time delay from onset to diagnosis was 12.0 ± 11.2 months. Age-gender standardized incidence rates with reference to Turkey, USA 2008 census were 1.9 (95% confidence interval (CI), 1.8-2.1), 1.9 (95%CI, 1.8-2.2) for overall. There were 112 living ALS patients at the end of the study. Crude point prevalence was calculated as 7.3 per 100,000 population (95%CI, 5.9-8.7).
This is the first study to provide fundamental data about demographic and clinical characteristics about ALS in Thrace region of Turkey. Incidence and prevalence of ALS in Thrace region of Turkey appear to be comparable with European countries.
本研究旨在调查土耳其色雷斯地区（2006-2010 年）五年间肌萎缩侧索硬化症（ALS）的发病率和患病率。
研究人群包括色雷斯地区三省（埃迪尔内、泰基尔达、基尔克拉雷利）的居民。病例从这些省份的所有神经科中心和医院中确定。为每位患者收集人口统计学和临床信息。符合埃尔埃斯科里亚尔修订诊断标准的新诊断 ALS 患者被纳入研究。
我们共确定了 145 名患者（93 名男性，52 名女性）。诊断时的平均年龄为 57.0±13.6 岁。根据埃尔埃斯科里亚尔标准，60.0%的病例为明确的 ALS，24.8%为可能的 ALS，15.2%为可能的 ALS。32 例为球部（22.1%），113 例（77.9%）为脊髓起病。从发病到诊断的平均时间延迟为 12.0±11.2 个月。参照土耳其和美国 2008 年人口普查，年龄性别标准化发病率为 1.9（95%置信区间（CI），1.8-2.1），总体为 1.9（95%CI，1.8-2.2）。研究结束时，有 112 名存活的 ALS 患者。粗点患病率计算为每 10 万人 7.3 例（95%CI，5.9-8.7）。
这是第一项提供土耳其色雷斯地区 ALS 人口统计学和临床特征基本数据的研究。土耳其色雷斯地区的 ALS 发病率和患病率似乎与欧洲国家相当。
