Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, 71-210 Szczecin, Poland.
Department of Neurology, Pomeranian Medical University, 71-252 Szczecin, Poland.
Medicina (Kaunas). 2020 Aug 5;56(8):390. doi: 10.3390/medicina56080390.
: Speech disorders are observed in 30% of newly diagnosed sporadic amyotrophic lateral sclerosis (ALS) patients. Characterized by a dynamic course, dysfunction of articulation has not so far been well understood. The aim of this study was to analyze the influence of demographic factors (sex, age, duration of the disease) and concomitant diseases (degenerative spine disease, depression, hypertension, hypothyroidism, hyperthyroidism, and allergy) on the functioning of speech organs in ALS patients. : The study group consisted of 65 patients with sporadic ALS. Patients were examined for articulatory functions by means of the Frenchay Dysarthria Assessment (FDA). : 68% of the study sample had spinal disorders. Logistic regression analysis showed that a decline in the functioning of lips, soft palate, length of phonation, and voice loudness was more common among men. Patients diagnosed with degenerative spine disease more often suffered from respiratory disorders, while younger patients (<60 years of age) significantly more often had the impairment of the sentence and spontaneous speech functions. : The male gender in patients with ALS is associated with an increased risk of deterioration of the phonation length function. Patients under 60 years of age are associated with more often pronouncing sentences disorders and spontaneous speech disorders.
: 在新诊断的散发性肌萎缩侧索硬化症(ALS)患者中,有 30%存在言语障碍。由于其具有动态病程,发音功能障碍至今尚未得到很好的理解。本研究旨在分析人口统计学因素(性别、年龄、疾病持续时间)和并存疾病(退行性脊柱疾病、抑郁症、高血压、甲状腺功能减退症、甲状腺功能亢进症和过敏)对 ALS 患者言语器官功能的影响。
: 研究组包括 65 例散发性 ALS 患者。采用 Frenchay 构音障碍评估(FDA)对患者的构音功能进行检查。
: 研究样本中有 68%存在脊柱疾病。逻辑回归分析显示,男性唇、软腭、发音长度和语音强度下降的发生率更高。诊断为退行性脊柱疾病的患者更常发生呼吸障碍,而年龄较小(<60 岁)的患者更常出现句子和自发言语功能障碍。
: ALS 患者的男性性别与发音长度功能恶化的风险增加相关。年龄在 60 岁以下的患者更常出现句子障碍和自发言语障碍。