Discipline of Anatomy & Histology, School of Medical sciences, Faculty of Medicine, The University of Sydney, Camperdown, Australia.
Discipline of Physiology, School of Medical sciences, Faculty of Medicine, The University of Sydney, Camperdown, Australia.
Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):466-471. doi: 10.1016/j.bbagen.2018.10.019. Epub 2018 Nov 22.
A healthy human can produce over 1 × 10 blood cells throughout their life. This remarkable amount of biomass requires a concomitantly vast amount of iron to generate functional haemoglobin and functional erythrocytes.
Erythroblasts form multicellular clusters with macrophages in the foetal liver, bone marrow and spleen termed erythroblastic islands. How the central erythroblastic island macrophage co-ordinates the supply of iron to the developing erythroblasts will be a central focus of this review.
Despite being studied for over 60 years, the mechanisms by which the erythroblastic island niche serves to control erythroid cell iron metabolism are poorly resolved.
Over 2 billion people suffer from some form of anaemia. Iron deficiency anaemia is the most prevalent form of anaemia. Therefore, understanding the processes by which iron is trafficked to, and metabolised in developing erythrocytes, is crucially important.
正常人的一生中可以生成超过 10 的 11 次方个血细胞。如此大量的生物量需要大量的铁来生成功能性血红蛋白和功能性红细胞。
成红细胞在胎儿肝脏、骨髓和脾脏中与巨噬细胞形成多细胞簇，称为成红细胞岛。中央成红细胞岛巨噬细胞如何协调向发育中的成红细胞供应铁将是本综述的重点。
尽管已经研究了 60 多年，但控制成红细胞铁代谢的成红细胞岛龛位的机制仍未得到很好的解决。
超过 20 亿人患有某种形式的贫血。缺铁性贫血是最常见的贫血形式。因此，了解铁向发育中的红细胞转运和代谢的过程至关重要。
