Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Ophthalmology, Federal University of São Paulo, São Paulo 04023-062, Brazil.
Int J Mol Sci. 2018 Nov 21;19(11):3688. doi: 10.3390/ijms19113688.
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in patients over the age of 65 years in industrialized countries. Epidemiologic studies suggest that high dietary fat intake is a risk factor for the development and progression of both vascular and retinal disease. These, and other associations, suggest a hypothesis linking elevated cholesterol and AMD progression. It follows, therefore, that cholesterol-lowering medications, such as statins, may influence the onset and progression of AMD. However, the findings have been inconclusive as to whether statins play a role in AMD. Due to the significant public health implications of a potential inhibitory effect of statins on the onset and progression of AMD, it is important to continually evaluate emerging findings germane to this question.
年龄相关性黄斑变性（AMD）是导致工业化国家 65 岁以上人群中心视力不可逆丧失的主要原因。流行病学研究表明，高脂肪饮食摄入是血管和视网膜疾病发生和进展的一个危险因素。这些以及其他关联，提出了一个假设，即胆固醇升高与 AMD 进展有关。因此，降低胆固醇的药物，如他汀类药物，可能会影响 AMD 的发生和进展。然而，他汀类药物是否在 AMD 中发挥作用的研究结果尚无定论。鉴于他汀类药物对 AMD 发生和进展可能具有抑制作用，这对公众健康具有重大影响，因此，不断评估与该问题相关的新发现非常重要。
