Schmidt Søren Fisker, Rohm Maria, Herzig Stephan, Berriel Diaz Mauricio
Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany.
Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany; Chair Molecular Metabolic Control, Technical University Munich, Germany.
Trends Cancer. 2018 Dec;4(12):849-860. doi: 10.1016/j.trecan.2018.10.001. Epub 2018 Oct 24.
Cancer cachexia is a multifactorial condition characterized by body weight loss that negatively affects quality of life and survival of patients with cancer. Despite the clinical relevance, there is currently no defined standard of care to effectively counteract cancer-associated progressive tissue wasting. Skeletal muscle atrophy represents the main manifestation of cancer cachexia. However, cancer cachexia is increasingly seen as a systemic phenomenon affecting and/or influenced by various organs. Here, we describe recent developments elucidating the roles of different tissues as well as tissue crosstalk in this wasting syndrome, including potential links to other cancer-associated morbidities. A more comprehensive understanding of cancer cachexia etiology and heterogeneity may enable the development of intervention strategies to prevent or reverse this devastating condition.
癌症恶病质是一种多因素病症，其特征为体重减轻，会对癌症患者的生活质量和生存产生负面影响。尽管具有临床相关性，但目前尚无明确的标准治疗方法来有效对抗癌症相关的进行性组织消耗。骨骼肌萎缩是癌症恶病质的主要表现。然而，癌症恶病质越来越被视为一种影响多个器官和/或受多个器官影响的全身性现象。在此，我们描述了阐明不同组织的作用以及这种消耗综合征中组织间相互作用的最新进展，包括与其他癌症相关发病机制的潜在联系。对癌症恶病质病因和异质性的更全面理解可能有助于制定干预策略，以预防或逆转这种毁灭性病症。
