Goo Hyun Woo
Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Pediatr Radiol. 2019 Mar;49(3):318-326. doi: 10.1007/s00247-018-4303-9. Epub 2018 Nov 23.
Semiautomatic three-dimensional (3-D) threshold-based cardiac computed tomography (CT) quantification has not been attempted for left ventricular mass.
To evaluate the technical feasibility of semiautomatic 3-D threshold-based cardiac CT quantification of left ventricular mass in patients with various degrees of left ventricular hypertrophy.
In 99 patients, cardiac CT was utilized to quantify ventricular volume and mass by using a semiautomatic 3-D threshold-based method. Left ventricular mass values were compared between the end-systole and the end-diastole. Volumetric parameters were compared among three left ventricular hypertrophy groups (definite, borderline, none). The reproducibility was assessed. The t-test, one-way analysis of variance and Pearson correlation were used.
There were no technical failures. The left ventricular mass between the two sessions exhibited a small mean difference of 2.3±1.1% (mean±standard deviation). The indexed mass values were significantly higher at the end-systole than at the end-diastole (71.4±42.9 g/m vs. 65.9±43.3 g/m, P<0.001), with significant correlation (R=0.99, P<0.001). The definite group (83.5±41.3 g/m) showed statistically significantly higher indexed mass values than the borderline and none groups (64.7±26.9 and 55.6±23.9 g/m, respectively; P<0.03), while demonstrating no statistically significant difference between the latter two groups (P>0.05). Left ventricular volume-mass and mass-volume ratios could be calculated in all three groups.
CT quantification of left ventricular mass using semiautomatic 3-D threshold-based segmentation is feasible with high reproducibility and the mass values and its ratios with ventricular volumes may be used in patients with various degrees of left ventricular hypertrophy.
基于半自动三维（3-D）阈值的心脏计算机断层扫描（CT）尚未尝试用于左心室质量的量化。
评估基于半自动3-D阈值的心脏CT对不同程度左心室肥厚患者左心室质量进行量化的技术可行性。
对99例患者使用基于半自动3-D阈值的方法，通过心脏CT对心室容积和质量进行量化。比较收缩末期和舒张末期的左心室质量值。在三个左心室肥厚组（明确肥厚、临界肥厚、无肥厚）之间比较容积参数。评估其可重复性。采用t检验、单因素方差分析和Pearson相关性分析。
无技术失败情况。两次测量之间的左心室质量平均差异较小，为2.3±1.1%（平均值±标准差）。指数化质量值在收缩末期显著高于舒张末期（71.4±42.9g/m² 对65.9±43.3g/m²，P<0.001），且具有显著相关性（R=0.99，P<0.001）。明确肥厚组（83.5±41.3g/m²）的指数化质量值在统计学上显著高于临界肥厚组和无肥厚组（分别为64.7±26.9g/m² 和55.6±23.9g/m²；P<0.03），而后两组之间无统计学显著差异（P>0.05）。所有三组均可计算左心室容积-质量和质量-容积比。
使用基于半自动3-D阈值分割的CT对左心室质量进行量化是可行的，具有高可重复性，质量值及其与心室容积的比值可用于不同程度左心室肥厚的患者。
