Böhling H G, Borchard U, Drouin H
Arch Toxicol. 1977 Nov 21;38(4):307-14. doi: 10.1007/BF00352035.
The influence of monomeric methylmethacrylate (MMA) on resting and compound action potential of the isolated desheathed sciatic nerve of the frog (sucrose gap method) was determined. Above 10 mM there was a dose-dependent decrease of the compound action potential and a hyperpolarization of the membrane which was augmented with increasing MMA concentrations (4.1 mV +/- 0.2 S.E.M. after 50 mM MMA). The depolarization in low [Ca2+]0 solutions or with veratrine was reversed by MMA. The homologous ethyl, allyl and n-butyl esters were more effective than MMA, and the isobutyl ester less effective, whereas Na-methacrylate and methacrylamide showed no influence. Voltage clamp experiments on the node of Ranvier indicated that 50 mM MMA led to a decrease of the Na+ and K+ currents.
测定了单体甲基丙烯酸甲酯（MMA）对青蛙离体去鞘坐骨神经静息电位和复合动作电位的影响（蔗糖间隙法）。浓度高于10 mM时，复合动作电位呈剂量依赖性降低，且膜发生超极化，随着MMA浓度增加超极化增强（50 mM MMA后为4.1 mV±0.2标准误）。低[Ca2+]0溶液或藜芦碱引起的去极化可被MMA逆转。同源的乙酯、烯丙酯和正丁酯比MMA更有效，而异丁酯效果较差，甲基丙烯酸钠和甲基丙烯酰胺则无影响。对郎飞结进行的电压钳实验表明，50 mM MMA导致Na+和K+电流降低。
