Husain R, Srivastava S P, Seth P K
Arch Toxicol. 1985 Oct;58(1):33-6. doi: 10.1007/BF00292613.
Methyl methacrylate (MMA), a widely used monomer in the manufacture of acrylic polymers, has been reported to cause neurological deficits in industrial workers. The effect of MMA on regional brain biogenic amines and their correlation with behavioural responses were examined. Male Wistar rats received orally MMA (500 mg/kg body wt) for 21 consecutive days. Our results indicate that MMA markedly impaired locomotor activity and learning, while aggressive behaviour significantly increased. An overall enhancement of biogenic amine levels in pons-medulla and hippocampus was noted. In addition, for noradrenaline an increase in cerebral cortex and corpus striatum, for 5-hydroxytryptamine an increase in mid-brain and hypothalamus and for dopamine a slight decrease in corpus striatum were recorded. The changes in regional brain biogenic amine levels may be partly responsible for altered behaviour.
甲基丙烯酸甲酯（MMA）是一种在丙烯酸聚合物制造中广泛使用的单体，据报道会导致产业工人出现神经功能缺损。研究了MMA对局部脑内生物胺的影响及其与行为反应的相关性。雄性Wistar大鼠连续21天口服MMA（500毫克/千克体重）。我们的结果表明，MMA显著损害运动活动和学习能力，同时攻击性行为显著增加。观察到脑桥延髓和海马中生物胺水平总体升高。此外，记录到大脑皮层和纹状体中去甲肾上腺素增加，中脑和下丘脑中5-羟色胺增加，纹状体中多巴胺略有减少。局部脑内生物胺水平的变化可能部分导致了行为改变。
