Huang Bo, Cui Sunliang
Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Drug Discov Today Technol. 2018 Nov;29:43-49. doi: 10.1016/j.ddtec.2018.09.001. Epub 2018 Sep 20.
Being important biological and pharmacological units, β-amino amides and β-acyloxy amides have a privileged position in both academia and industry. Developing a methods to prepare them has gained attention. Ynamides, which possess dual nucleophilic and electrophilic properties, are similar to isonitriles. In this review, usage of ynamides in the single reactant replacement approach of Ugi and Passerini reactions to develop two new multicomponent reactions to get various β-amino amides and β-acyloxy amides is reported.
作为重要的生物和药理单元，β-氨基酰胺和β-酰氧基酰胺在学术界和工业界都具有特殊地位。开发制备它们的方法已受到关注。具有亲核和亲电双重性质的烯炔酰胺与异腈类似。在本综述中，报道了烯炔酰胺在乌吉反应和帕塞里尼反应的单反应物替代方法中的应用，以开发两种新的多组分反应来获得各种β-氨基酰胺和β-酰氧基酰胺。
