Tan Joanne, Yudin Andrei K
Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.
Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.
Drug Discov Today Technol. 2018 Nov;29:51-60. doi: 10.1016/j.ddtec.2018.08.002. Epub 2018 Sep 10.
Over the past two decades, there has been an increasing interest in the therapeutic potential of organoboron reagents due to the discovery of bortezomib (Velcade). This has motivated synthetic chemists to develop novel routes for the preparation of heteroatom-rich boron-containing molecules (BCMs). In particular, the development of borylated building blocks has provided facile access to difficult-to-access heteroatom-rich BCMs. In this review, we will discuss the methods used to prepare boron-containing molecules of biological relevance from multicomponent reactions with borylated building blocks.
在过去二十年中，由于硼替佐米（万珂）的发现，人们对有机硼试剂的治疗潜力越来越感兴趣。这促使合成化学家开发新的路线来制备富含杂原子的含硼分子（BCMs）。特别是，硼化砌块的开发为难以获得的富含杂原子的BCMs提供了便捷的合成途径。在这篇综述中，我们将讨论利用硼化砌块通过多组分反应制备具有生物学相关性的含硼分子的方法。
