Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong, Shanghai 201203, China.
Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong, Shanghai 201203, China.
Gene. 2019 Mar 1;687:255-260. doi: 10.1016/j.gene.2018.11.063. Epub 2018 Nov 22.
Mounting evidence has shown that long noncoding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) in distinct physiological and pathological states. The activation of hepatic stellate cells (HSCs) is a critical event in the development of hepatic fibrosis (HF). LncRNAs have recently been revealed to be involved in HSC activation as ceRNAs. CeRNA analysis tremendously expands the functional information of proteins, DNA and coding and noncoding RNA. In addition, many validated ceRNA networks, including the traditional ceRNA/mRNA/miRNA, participate in the initiation and progress of HF, and additional work is needed in elucidating the potential of ceRNAs in precancer diagnosis, prognosis and providing new therapeutic methods for HF reversion.
越来越多的证据表明，长链非编码 RNA（lncRNA）可以在不同的生理和病理状态下作为竞争性内源 RNA（ceRNA）发挥作用。肝星状细胞（HSCs）的激活是肝纤维化（HF）发展过程中的一个关键事件。最近的研究表明，lncRNA 作为 ceRNA 参与 HSC 的激活。ceRNA 分析极大地扩展了蛋白质、DNA 和编码及非编码 RNA 的功能信息。此外，许多经过验证的 ceRNA 网络，包括传统的 ceRNA/mRNA/miRNA，参与 HF 的起始和进展，需要进一步研究 ceRNAs 在癌前诊断、预后中的潜力，并为 HF 的逆转提供新的治疗方法。
