Program in Physical Therapy and Department of Neurology, Wayne State University, Detroit, MI, United States; Division of Physical Therapy, The Ohio State University, Columbus, OH, United States; School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, United States.
Division of Physical Therapy, The Ohio State University, Columbus, OH, United States; School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, United States.
J Neurol Sci. 2019 Jan 15;396:159-164. doi: 10.1016/j.jns.2018.11.015. Epub 2018 Nov 10.
Despite the prevalence of dual-task (e.g., walking while talking) deficits in people with multiple sclerosis (MS), no neuroimaging studies to date have examined neuronal networks used for dual-task processing or specific brain areas related to dual-task performance in this population. A better understanding of the relationship among underlying brain areas and dual-task performance may improve targeted rehabilitation programs. The objective of this study was to examine relationships between neuroimaging measures and clinical measures of dual-task performance, and reported falls in persons with MS.
All participants completed measures of dual-task performance, a fall history, and neuroimaging on a 3 T MRI scanner. Spearman correlations were used to examine relationships among dual-task performance, falls and neuroimaging measures.
Eighteen females with relapsing-remitting MS [mean age = 45.5 ± 8.2 SD; mean symptom duration = 12.3 ± 6.7 years; Expanded Disability Status Scale median 2.25 (range 1.5-4)] participated in this study. Structural imaging measures of supplementary motor area (SMA) interhemispheric connectivity were significantly related to dual-task walking variability.
The SMA interhemispheric tract may play a role in dual-task performance. Structural neuroimaging may be a useful adjunct to clinical measures to predict performance and provide information about recovery patterns in MS. Functional recovery can be challenging to objectively report in MS; diffusion tensor imaging could show microstructural improvements and suggest improved connectivity.
尽管多发性硬化症（MS）患者普遍存在双重任务（例如，行走时说话）缺陷，但迄今为止，尚无神经影像学研究检查过用于双重任务处理的神经元网络或与该人群双重任务表现相关的特定大脑区域。更好地了解潜在大脑区域与双重任务表现之间的关系可能会改善针对性的康复计划。本研究的目的是检查多发性硬化症患者的神经影像学测量值与双重任务表现和报告的跌倒之间的关系。
所有参与者都完成了双重任务表现、跌倒史和 3T MRI 扫描仪的神经影像学检查。使用 Spearman 相关分析来检查双重任务表现、跌倒和神经影像学测量值之间的关系。
18 名患有复发缓解型 MS 的女性[平均年龄 45.5 ± 8.2 岁；平均症状持续时间 12.3 ± 6.7 年；扩展残疾状况量表中位数为 2.25（范围 1.5-4）]参加了这项研究。补充运动区（SMA）半球间连通性的结构影像学测量值与双重任务行走变异性显着相关。
SMA 半球间束可能在双重任务表现中起作用。结构神经影像学可能是临床测量的有用补充，可以预测表现并提供有关 MS 恢复模式的信息。MS 中功能恢复难以客观报告；弥散张量成像可以显示微观结构的改善并提示改善的连通性。
