Koh Hyun Min, An Hyo Jung, Ko Gyung Hyuck, Lee Jeong Hee, Lee Jong Sil, Kim Dong Chul, Yang Jung Wook, Kim Min Hye, Kim Sung Hwan, Jeon Kyung Nyeo, Lee Gyeong-Won, Jang Se Min, Song Dae Hyun
Department of pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea.
Gyeongsang National University School of Medicine, Jinju, Korea.
J Pathol Transl Med. 2019 Jan;53(1):13-22. doi: 10.4132/jptm.2018.11.12. Epub 2018 Nov 26.
S100A8 and S100A9 have been gaining recognition for modulating tumor growthand metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 innon-small cell lung cancer (NSCLC).
We analyzed the relationship between S100A8and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumorcells and peritumoral inflammatory cells.
The positive staining of S100A8 in tumorcells was significantly increased in male (p < .001), smoker (p = .034), surgical method other thanlobectomy (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022)compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. Theproportion of tumor cells stained for S100A8 was related to histologic type (p < .001) and patientsex (p = .027). The proportion of inflammatory cells stained for S100A8 was correlated with patientage (p = .022), whereas the proportion of inflammatory cells stained for S100A9 was correlatedwith patient sex (p < .001) and smoking history (p = .031). Moreover, positive staining in tumorcells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cellsstained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCCbut towards decreased survivability in ADC.
S100A8 and S100A9 expressions might be potential prognostic markers in patients with NSCLC.
S100A8和S100A9在调节肿瘤生长和转移方面日益受到关注。本研究旨在评估S100A8和S100A9在非小细胞肺癌（NSCLC）中的临床意义。
我们分析了肿瘤细胞和瘤周炎性细胞中S100A8和S100A9表达、临床病理特征及预后意义之间的关系。
与女性、非吸烟者、肺叶切除术、腺癌（ADC）及较低分期相比，肿瘤细胞中S100A8的阳性染色在男性（p < 0.001）、吸烟者（p = 0.034）、非肺叶切除术的手术方式（p = 0.024）、鳞状细胞癌（SQCC）（p < 0.001）及较高TNM分期（p = 0.022）中显著增加。肿瘤细胞中S100A8染色的比例与组织学类型（p < 0.001）和患者性别（p = 0.027）有关。S100A8染色的炎性细胞比例与患者年龄相关（p = 0.022），而S100A9染色的炎性细胞比例与患者性别（p < 0.001）和吸烟史（p = 0.031）相关。此外，肿瘤细胞中的阳性染色、超过50%的肿瘤细胞被S100A和S100A9染色以及少于30%的炎性细胞被染色表明，SQCC患者的生存能力有增加趋势，而ADC患者的生存能力有降低趋势。
S100A8和S100A9表达可能是NSCLC患者潜在的预后标志物。
