Liu W, Xiao H, Wu S, Liu H, Luo B
Acta Virol. 2018;62(4):435-440. doi: 10.4149/av_2018_412.
Microtubule-associated protein 9 (MAP9) is a mitosis-associated protein involved in bipolar spindle assembly. Following DNA damage, MAP9 stabilizes p53 via p300 and MDM2 (mouse double minute-2 homolog). The dysregulation of MAP9 was considered to be associated with tumorigenesis. Single nucleotide polymorphisms (SNPs) in key genes governing mitosis may particularly increase susceptibility to gastric carcinoma (GC). Our study demonstrated that the CC homozygous genotype of SNP rs1058992 located in the MAP9 gene was significantly correlated with EBV-associated GC (EBVaGC) in a recessive genetic model (OR = 2.558, 95% CI = 1.306-5.010, P = 0.043), and the C allele frequency of rs1058992 also showed significant correlation with EBVaGC (OR = 1.904, 95% CI = 1.141-3.179, P = 0.013). These results suggest that the MAP9 rs1058992 polymorphism is associated with risk of EBVaGC. The conversion of lysine to arginine caused by rs1058992 may affect development of EBVaGC; however, further studies in larger populations are needed to fully elucidate its role in EBVaGC. Keywords: SNP; EBV; gastric carcinoma; MAP9.
微管相关蛋白9（MAP9）是一种与有丝分裂相关的蛋白，参与双极纺锤体组装。DNA损伤后，MAP9通过p300和MDM2（小鼠双微体2同源物）使p53稳定。MAP9的失调被认为与肿瘤发生有关。调控有丝分裂的关键基因中的单核苷酸多态性（SNP）可能会特别增加患胃癌（GC）的易感性。我们的研究表明，位于MAP9基因的SNP rs1058992的CC纯合基因型在隐性遗传模型中与EB病毒相关胃癌（EBVaGC）显著相关（OR = 2.558，95%CI = 1.306 - 5.010，P = 0.043），并且rs1058992的C等位基因频率也与EBVaGC显著相关（OR = 1.904，95%CI = 1.141 - 3.179，P = 0.013）。这些结果表明，MAP9 rs1058992多态性与EBVaGC的风险相关。rs1058992导致的赖氨酸向精氨酸的转变可能会影响EBVaGC的发生发展；然而，需要在更大规模人群中进行进一步研究，以充分阐明其在EBVaGC中的作用。关键词：单核苷酸多态性；EB病毒；胃癌；MAP9
