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解读 H7N9 人间感染病例的急剧下降

Deciphering the Sharp Decrease in H7N9 Human Infections.

机构信息

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou 510642, China.

出版信息

Trends Microbiol. 2018 Dec;26(12):971-973. doi: 10.1016/j.tim.2018.10.002. Epub 2018 Oct 25.

DOI:10.1016/j.tim.2018.10.002
PMID:30472993
Abstract

The H7N9 virus has caused five waves of human infections since 2013. However, human infections have almost disappeared in the past year. In a recent study, Shi et al. revealed that the usage of a bivalent H5/H7 vaccine successfully prevented chicken infections, and thus prevented, and nearly eliminated, human infections.

摘要

自 2013 年以来,H7N9 病毒已导致人类感染了五波疫情。然而,在过去的一年中,人类感染几乎消失了。在最近的一项研究中,Shi 等人揭示了使用二价 H5/H7 疫苗成功地预防了鸡感染,从而阻止并几乎消除了人类感染。

相似文献

1
Deciphering the Sharp Decrease in H7N9 Human Infections.解读 H7N9 人间感染病例的急剧下降
Trends Microbiol. 2018 Dec;26(12):971-973. doi: 10.1016/j.tim.2018.10.002. Epub 2018 Oct 25.
2
Newcastle Disease Virus-Vectored H7 and H5 Live Vaccines Protect Chickens from Challenge with H7N9 or H5N1 Avian Influenza Viruses.新城疫病毒载体H7和H5活疫苗可保护鸡免受H7N9或H5N1禽流感病毒的攻击。
J Virol. 2015 Jul;89(14):7401-8. doi: 10.1128/JVI.00031-15. Epub 2015 Apr 29.
3
Recombinant baculovirus vaccine expressing hemagglutinin of H7N9 avian influenza virus confers full protection against lethal highly pathogenic H7N9 virus infection in chickens.表达H7N9禽流感病毒血凝素的重组杆状病毒疫苗可使鸡完全抵御高致病性H7N9病毒的致死性感染。
Arch Virol. 2019 Mar;164(3):807-817. doi: 10.1007/s00705-018-04142-4. Epub 2019 Jan 22.
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Protective efficacy of an inactivated chimeric H7/H5 avian influenza vaccine against highly pathogenic avian influenza H7N9 and clade 2.3.4.4 H5 viruses.一种灭活嵌合 H7/H5 禽流感疫苗对高致病性禽流感 H7N9 和 2.3.4.4 分支 H5 病毒的保护效力。
Vet Microbiol. 2018 Sep;223:21-26. doi: 10.1016/j.vetmic.2018.07.011. Epub 2018 Jul 17.
5
220 mutation in the hemagglutinin of avian influenza A (H7N9) virus alters antigenicity during vaccine strain development.220 位点突变使禽流感病毒(H7N9)血凝素发生改变,从而影响疫苗株的抗原性。
Hum Vaccin Immunother. 2018 Mar 4;14(3):532-539. doi: 10.1080/21645515.2017.1419109. Epub 2018 Feb 1.
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A recombinant H7N9 influenza vaccine with the H7 hemagglutinin transmembrane domain replaced by the H3 domain induces increased cross-reactive antibodies and improved interclade protection in mice.一种将H7血凝素跨膜结构域替换为H3结构域的重组H7N9流感疫苗可诱导小鼠产生更多的交叉反应抗体,并增强不同进化枝间的保护作用。
Antiviral Res. 2017 Jul;143:97-105. doi: 10.1016/j.antiviral.2017.03.029. Epub 2017 Apr 10.
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Enhanced humoural and cellular immune responses to influenza H7N9 antigen HA1-2 fused with flagellin in chickens.鸡对与鞭毛蛋白融合的流感H7N9抗原HA1-2的体液免疫和细胞免疫反应增强。
BMC Vet Res. 2017 Jun 21;13(1):190. doi: 10.1186/s12917-017-1106-4.
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Development of influenza H7N9 virus like particle (VLP) vaccine: homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus.流感 H7N9 病毒样颗粒(VLP)疫苗的研制:同源 A/Anhui/1/2013(H7N9)保护和异源 A/鸡/哈利斯科/CPIA1/2012(H7N3)对接种疫苗的小鼠用 H7N9 病毒攻毒的交叉保护作用。
Vaccine. 2013 Sep 13;31(40):4305-13. doi: 10.1016/j.vaccine.2013.07.043. Epub 2013 Jul 26.
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Emergence and Adaptation of a Novel Highly Pathogenic H7N9 Influenza Virus in Birds and Humans from a 2013 Human-Infecting Low-Pathogenic Ancestor.一种新型高致病性H7N9流感病毒从2013年感染人类的低致病性祖先毒株在鸟类和人类中出现及适应性演变。
J Virol. 2018 Jan 2;92(2). doi: 10.1128/JVI.00921-17. Print 2018 Jan 15.
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Evaluation of the Immune Responses to and Cross-Protective Efficacy of Eurasian H7 Avian Influenza Viruses.欧亚H7禽流感病毒免疫反应及交叉保护效力评估
J Virol. 2017 May 12;91(11). doi: 10.1128/JVI.02259-16. Print 2017 Jun 1.

引用本文的文献

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Bayesian phylodynamics reveals the transmission dynamics of avian influenza A(H7N9) virus at the human-live bird market interface in China.贝叶斯系统发育动力学揭示了中国活禽市场界面中甲型流感 H7N9 病毒的传播动态。
Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2215610120. doi: 10.1073/pnas.2215610120. Epub 2023 Apr 17.
2
Computational predicting the human infectivity of H7N9 influenza viruses isolated from avian hosts.计算预测源自禽源宿主的 H7N9 流感病毒对人类的感染力。
Transbound Emerg Dis. 2021 Mar;68(2):846-856. doi: 10.1111/tbed.13750. Epub 2020 Aug 8.
3
Geographical variation in the risk of H7N9 human infections in China: implications for risk-based surveillance.
中国 H7N9 人间感染风险的地理变异:基于风险的监测意义。
Sci Rep. 2020 Jun 25;10(1):10372. doi: 10.1038/s41598-020-66359-1.
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Comparison of Avian Influenza Virus Contamination in the Environment Before and After Massive Poultry H5/H7 Vaccination in Zhejiang Province, China.中国浙江省大规模家禽H5/H7疫苗接种前后环境中禽流感病毒污染情况比较
Open Forum Infect Dis. 2019 Apr 24;6(6):ofz197. doi: 10.1093/ofid/ofz197. eCollection 2019 Jun.