University Women's Hospital, Division of Gynaecological Endocrinology and Reproductive Medicine, Inselspital, University Hospital, Berne, Switzerland.
Best Pract Res Clin Endocrinol Metab. 2019 Feb;33(1):35-45. doi: 10.1016/j.beem.2018.10.005. Epub 2018 Nov 9.
Natural Cycle IVF (NC-IVF) with and without modifications is being increasingly performed. NC-IVF and conventional gonadotropin-stimulated IVF (cIVF) should not be understood as competing treatments, but as complementary treatments with different target groups and to some extent other indications. NC-IVF is particularly interesting for couples who wish to save money, wish a treatment with as few risks as possible and for women who would like to avoid selection and cryopreservation of embryos. NC-IVF therefore contributes to the concept of individualized and patient-oriented therapy. The time to pregnancy is slightly longer than with conventional IVF. NC-IVF is particularly suitable for younger women and for women with a very low ovarian reserve. In this article, the principles of NC-IVF, i.e. monofollicular IVF without gonadotropin stimulation, are described and the technical differences to cIVF, advantages and disadvantages, perinatal outcome and indications for NC-IVF are highlightened.
自然周期 IVF（NC-IVF）及其改良方案的应用正在逐渐增多。NC-IVF 和常规促性腺激素刺激 IVF（cIVF）不应被视为相互竞争的治疗方法，而应被视为具有不同目标人群和在一定程度上具有其他适应证的互补治疗方法。NC-IVF 特别适用于希望节省费用、希望治疗风险尽可能低以及希望避免胚胎选择和冷冻的夫妇。因此，NC-IVF 有助于实现个体化和以患者为中心的治疗理念。妊娠时间比常规 IVF 略长。NC-IVF 特别适用于年轻女性和卵巢储备功能非常低的女性。本文描述了 NC-IVF 的原则，即无需促性腺激素刺激的单卵泡 IVF，并强调了与 cIVF 的技术差异、优势和劣势、围产期结局以及 NC-IVF 的适应证。
