Ffrench-Constant C, Miller R H, Burne J F, Raff M C
Department of Cell Biology, University College, London, UK.
J Neurocytol. 1988 Feb;17(1):13-25. doi: 10.1007/BF01735374.
There is evidence that oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells migrate along the developing rat optic nerve from the chiasm toward the eye before differentiating into oligodendrocytes that myelinate the retinal ganglion cell axons in the nerve. Why, then, do these progenitor cells not migrate into the eye, differentiate into oligodendrocytes and myelinate the nerve fibre layer of the retina? Myelination would opacify the neural retina and thereby severely impair vision. Here we provide evidence that there is a barrier at the eye-end of the rat optic nerve that prevents the migration of O-2A progenitor cells into the retina. Our findings in the rat support a previous hypothesis that such a barrier keeps myelin-forming glial cells out of the human retina.
有证据表明，少突胶质细胞-2型星形胶质细胞（O-2A）祖细胞在分化为少突胶质细胞之前，沿着发育中的大鼠视神经从视交叉向眼睛迁移，这些少突胶质细胞会使神经中的视网膜神经节细胞轴突髓鞘化。那么，为什么这些祖细胞不迁移到眼睛中，分化为少突胶质细胞并使视网膜的神经纤维层髓鞘化呢？髓鞘化会使神经视网膜变得不透明，从而严重损害视力。在这里，我们提供证据表明，大鼠视神经的眼端存在一个屏障，可阻止O-2A祖细胞迁移到视网膜中。我们在大鼠身上的发现支持了之前的一个假设，即这样的屏障可防止形成髓鞘的神经胶质细胞进入人类视网膜。
