College of Optometry, University of Houston, Houston, TX, USA.
College of Optometry, University of Houston, Houston, TX, USA.
Clin Neurophysiol. 2019 Jan;130(1):180-188. doi: 10.1016/j.clinph.2018.10.007. Epub 2018 Nov 13.
To examine the relationship between optical coherence tomography (OCT) macular ganglion cell-inner plexiform layer thickness (GCIPLT), peripapillary retinal nerve fiber layer thickness (RNFLT) and visual function in relapsing-remitting multiple sclerosis (RRMS).
Cirrus OCT, VERIS 60-sector multifocal visual evoked potential (mfVEP) and Pelli-Robson contrast sensitivity (CS) were obtained for 53 eyes with last optic neuritis (ON) > 6 months and 105 non-ON eyes in 90 patients. One eye (43 ON, 73 non-ON) was used for correlations when both had the same history. Global (G, 60 sectors) and central 5.6° (C, 24 sectors) mfVEP amplitude and latency were calculated as mean logSNR and median latency.
Eyes showing abnormal mfVEP (amplitude or latency) vs OCT (GCIPLT or RNFLT) was 77% vs 69% (p = 0.33) in ON, 45% vs 22% (p < 0.0005) in non-ON. In ON and non-ON, mfVEP measures and CS correlated with GCIPLT and RNFLT (r = -0.24 to 0.78, p = 0.03-0.0001). In ON, mfVEP amplitude (C,G) correlated better with GCIPLT (r = 0.78, 0.76) than RNFLT (r = 0.43, 0.58; p < 0.001, 0.01).
MfVEP measures and CS correlated well with GCIPLT and RNFLT in ON and non-ON. MfVEP amplitudes were more highly correlated with GCIPLT than RNFLT in ON. MfVEP detected significantly more defects than OCT in non-ON.
GCIPLT, mfVEP and CS provide useful measures of optic nerve integrity in RRMS.
探讨光学相干断层扫描（OCT）黄斑神经节细胞-内丛状层厚度（GCIPLT）、视盘周围视网膜神经纤维层厚度（RNFLT）与复发缓解型多发性硬化症（RRMS）患者视力的关系。
对 90 例患者的 53 只曾患视神经炎（ON）眼（ON 眼）和 105 只未患视神经炎眼（非 ON 眼）进行 Cirrus OCT、VERIS 60 区多焦视觉诱发电位（mfVEP）和 Pelli-Robson 对比敏感度（CS）检查。当两只眼具有相同病史时，使用其中一只眼（43 只 ON 眼和 73 只非 ON 眼）进行相关性分析。计算平均对数信噪比（logSNR）和中位数潜伏期作为整体（G，60 区）和中央 5.6°（C，24 区）mfVEP 的振幅和潜伏期。
ON 眼和非 ON 眼中，mfVEP 检查（振幅或潜伏期）异常而 OCT 检查（GCIPLT 或 RNFLT）正常的比例分别为 77%和 69%（p=0.33）；mfVEP 检查异常而 OCT 检查正常的比例分别为 45%和 22%（p<0.0005）。ON 眼和非 ON 眼中，mfVEP 测量值和 CS 与 GCIPLT 和 RNFLT 相关（r=-0.24 至 0.78，p=0.03-0.0001）。在 ON 眼，mfVEP 振幅（C，G）与 GCIPLT 的相关性优于 RNFLT（r=0.78，0.76 比 r=0.43，0.58；p<0.001，0.01）。
ON 眼和非 ON 眼中，mfVEP 测量值和 CS 与 GCIPLT 和 RNFLT 相关性良好。在 ON 眼，mfVEP 振幅与 GCIPLT 的相关性优于 RNFLT。非 ON 眼中，mfVEP 比 OCT 检测到更多的异常。
GCIPLT、mfVEP 和 CS 为 RRMS 视神经完整性提供了有用的测量指标。
