Chen Hanze, Xue Weishuang, Li Jinwei, Fu Kailei, Shi Han, Zhang Beidi, Teng Weiyu, Tian Li
Deparment of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China.
Clinical Department one, China Medical University, Shenyang, China.
Front Aging Neurosci. 2018 Nov 9;10:368. doi: 10.3389/fnagi.2018.00368. eCollection 2018.
Conclusions of previous cohort studies on the relationship between 25-hydroxyvitamin D level and the risk of dementia and Alzheimer's disease were not consistent. Thus, we performed a dose-response meta-analysis to evaluate this relationship by summarizing cohort studies. Pubmed, Embase, Cochrane, and Web of Science databases were searched for relevant studies. Cohort studies concerning the association between 25-hydroxyvitamin D level and dementia or Alzheimer's disease were included. Results of studies were pooled and the dose-response relationship was determined using a random-effect model. Ten cohort studies, with 28,640 participants were included. A significant inverse relationship was found between 25-hydroxyvitamin D level and the risk of dementia and Alzheimer's disease. In addition, we found a linear dose-response relationship in that a 10 nmol/L increase in 25-hydroxyvitamin D level may lead to a 5% decrease in the risk of dementia (relative risk, 0.95; 95% confidence interval, 0.93-0.98) and 7% in the risk of Alzheimer's disease (relative risk, 0.93; 95% confidence interval, 0.89-0.97). Plasma or serum 25-hydroxyvitamin D concentration was inversely related to the risk of dementia and Alzheimer's disease, consistent with a linear dose-response relationship.
先前关于25-羟基维生素D水平与痴呆症和阿尔茨海默病风险之间关系的队列研究结论并不一致。因此，我们进行了一项剂量反应荟萃分析，通过总结队列研究来评估这种关系。我们在PubMed、Embase、Cochrane和科学网数据库中检索了相关研究。纳入了关于25-羟基维生素D水平与痴呆症或阿尔茨海默病之间关联的队列研究。汇总了研究结果，并使用随机效应模型确定剂量反应关系。纳入了10项队列研究，共28640名参与者。发现25-羟基维生素D水平与痴呆症和阿尔茨海默病风险之间存在显著的负相关关系。此外，我们发现了一种线性剂量反应关系，即25-羟基维生素D水平每升高10 nmol/L，痴呆症风险可能降低5%（相对风险，0.95；95%置信区间，0.93-0.98），阿尔茨海默病风险降低7%（相对风险，0.93；95%置信区间，0.89-0.97）。血浆或血清25-羟基维生素D浓度与痴呆症和阿尔茨海默病风险呈负相关，与线性剂量反应关系一致。
