老年人维生素 D 浓度较低与认知能力下降及痴呆和阿尔茨海默病长期风险的关联。
Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults.
机构信息
INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
出版信息
Alzheimers Dement. 2017 Nov;13(11):1207-1216. doi: 10.1016/j.jalz.2017.03.003. Epub 2017 May 16.
INTRODUCTION
Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent.
METHODS
The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years.
RESULTS
In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37-5.97).
DISCUSSION
This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology.
简介
维生素 D 缺乏与多种慢性疾病有关；然而，其与认知能力下降以及痴呆和阿尔茨海默病（AD）的风险之间的关联尚不一致。
方法
本研究的研究对象为来自波尔多三城队列的 916 名 65 岁以上的参与者，在基线时无痴呆，评估了维生素 D 状况，并随访了长达 12 年。
结果
在多变量分析中，与 25(OH)D 充足的个体（n=151）相比，25(OH)D 缺乏的个体（n=218）表现出更快的认知能力下降。共发生 177 例痴呆病例（124 例 AD）：25(OH)D 缺乏与 AD 的风险增加近三倍相关（风险比=2.85，95%置信区间 1.37-5.97）。
讨论
这项针对法国老年人的大型前瞻性研究表明，在老年时保持足够的维生素 D 状态可能有助于减缓认知能力下降，并延迟或预防痴呆的发生，特别是 AD 病因。
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