State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012, China.
Nanoscale. 2018 Dec 21;10(47):22155-22160. doi: 10.1039/c8nr07288d. Epub 2018 Nov 26.
For the first time, an ultrathin iron-porphyrin based polymer nanocapsule with multiple peroxidase-like catalytic centers was constructed by covalently assembling iron-porphyrin monomers; this nanocapsule with a single molecule thickness shell acted as a highly efficient artificial enzyme for mimicking peroxidase. On the basis of the peroxidase-like activity of Fe-TPyP based nanocapsules (Fe-TPyP NCs), a highly sensitive colorimetric sensor for glucose determination was fabricated, the limit of detection was found to be as low as 0.098 μM. This study provided a novel strategy for developing artificial enzymes based on covalently assembled nanostructures. Furthermore, the colorimetric sensor for glucose determination showed potential applications in biomedicine and biology.
首次通过共价组装铁卟啉单体构建了具有多个过氧化物酶样催化中心的超薄铁卟啉基聚合物纳米胶囊；这种具有单分子厚度壳的纳米胶囊充当了高效的人工酶，可模拟过氧化物酶。基于 Fe-TPyP 基纳米胶囊（Fe-TPyP NCs）的过氧化物酶样活性，构建了用于葡萄糖测定的高灵敏比色传感器，检测限低至 0.098 μM。本研究为开发基于共价组装纳米结构的人工酶提供了一种新策略。此外，用于葡萄糖测定的比色传感器在生物医学和生物学中具有潜在的应用。
