Mizushima Ichiro, Kasashima Satomi, Fujinaga Yasunari, Kawano Mitsuhiro, Ishizaka Nobukazu
a Division of Rheumatology , Kanazawa University Hospital , Kanazawa , Japan.
b Department of Cardiovascular and Internal Medicine , Kanazawa University Hospital , Kanazawa , Japan.
Mod Rheumatol. 2019 Mar;29(2):240-250. doi: 10.1080/14397595.2018.1546367.
Periaortitis and periarteritis are one of the clinical features of IgG4-related disease. Such vascular manifestations are reported to be present in 10-30% of overall IgG4-related disease, and they may also appear as an isolated lesion of IgG4-related disease. As other types of large vessel vasculitis, IgG4-related vasculitis may cause significant clinical consequences. On the other hand, the diagnosis of IgG4-related periaortitis/periarteritis seems to have been made on the basis of different diagnostic criteria in reported studies; thus far, difficulty seems to be present in assessing the true frequency of the disease as well as determining the optimal therapeutic strategy. In this review, in addition presenting the clinical and pathological features of IgG4-related periaortitis/periarteirtis, we would like to discuss on what kind of points should be resolved for the better understanding of vascular involvement of IgG4-related disease in terms of diagnosis and treatment.
主动脉周炎和动脉周炎是IgG4相关疾病的临床特征之一。据报道，此类血管表现存在于10%至30%的IgG4相关疾病患者中，它们也可能表现为IgG4相关疾病的孤立病变。与其他类型的大血管血管炎一样，IgG4相关血管炎可能会导致严重的临床后果。另一方面，在已发表的研究中，IgG4相关主动脉周炎/动脉周炎的诊断似乎是基于不同的诊断标准；到目前为止，在评估该疾病的真实发病率以及确定最佳治疗策略方面似乎都存在困难。在本综述中，除了介绍IgG4相关主动脉周炎/动脉周炎的临床和病理特征外，我们还想讨论在诊断和治疗方面，为更好地理解IgG4相关疾病的血管受累情况需要解决哪些问题。
