Campbell T Mark, Reilly Katherine, Goudreau Louis, Laneuville Odette, Uhthoff Hans, Trudel Guy
Elizabeth Bruyère Hospital; The Bone and Joint Research Laboratory, University of Ottawa; Department of Medicine, University of Ottawa;
The Bone and Joint Research Laboratory, University of Ottawa; Department of Medicine, University of Ottawa.
J Vis Exp. 2018 Nov 9(141). doi: 10.3791/58084.
Normal knee range of motion (ROM) is critical to well-being and allows one to perform basic activities such as walking, climbing stairs and sitting. Lost ROM is called a joint contracture and results in increased morbidity. Due to the difficulty of reversing established knee contractures, early detection is important, and hence, knowing risk factors for their development is essential. The rat represents a good model with which the effect of an intervention can be studied due to the similarity of rat knee anatomy to that of humans, the rat's ability to tolerate long durations of knee immobilization in flexion, and because mechanical data can be correlated with histologic and biochemical analysis of knee tissue. Using an automated arthrometer, we demonstrate a validated, precise, reproducible, user-independent method of measuring the extension ROM of the rat knee joint at specific torques. This arthrometer can be used to determine the effects of interventions on knee joint ROM in the rat.
正常的膝关节活动范围（ROM）对健康至关重要，它能使人进行诸如行走、爬楼梯和坐下等基本活动。ROM丧失被称为关节挛缩，会导致发病率增加。由于逆转已形成的膝关节挛缩存在困难，早期检测很重要，因此，了解其发生的风险因素至关重要。大鼠是一个很好的模型，由于大鼠膝关节解剖结构与人类相似，大鼠能够耐受长时间的膝关节屈曲固定，并且机械数据可以与膝关节组织的组织学和生化分析相关联，所以可以用它来研究干预措施的效果。使用自动关节测量仪，我们展示了一种经过验证的、精确的、可重复的、独立于用户的方法，用于在特定扭矩下测量大鼠膝关节的伸展ROM。这种关节测量仪可用于确定干预措施对大鼠膝关节ROM的影响。
