Jauniaux E, Elkazen N, Leroy F, Wilkin P, Rodesch F, Hustin J
Department of Obstetrics and Gynecology, Hospital Universitaire Erasme, Belgium.
Obstet Gynecol. 1988 Oct;72(4):577-81.
The pathologic findings in placentas from ten multiple gestations complicated by the so-called vanishing twin phenomenon were studied to confirm the ultrasonographic evidence. Five pregnancies resulted from in vitro fertilization and embryo transfer, and five conceptions were spontaneous. The pregnancies were studied by repeat ultrasound examinations between five and 12 weeks' gestation. First-trimester bleeding was the only clinical sign of this phenomenon. Postpartum evidence of the vanishing twin phenomenon was found in five cases. Morphologically, the lesions were characterized by well-delineated plaques of perivillous fibrin deposition, associated in one case with embryonic remnants. This focal degenerative change of the placental mass, which also exists in about 25% of placentas from uncomplicated term pregnancies, may be the only clue to the disappearance of one conceptus.
研究了10例合并所谓消失双胎现象的多胎妊娠胎盘的病理表现，以证实超声检查结果。5例妊娠为体外受精和胚胎移植，5例为自然受孕。在妊娠5至12周期间通过重复超声检查对这些妊娠进行研究。孕早期出血是该现象的唯一临床体征。5例病例发现了产后消失双胎现象的证据。形态学上，病变的特征是绒毛周围纤维蛋白沉积形成界限清楚的斑块，1例伴有胚胎残余物。胎盘组织的这种局灶性退行性改变在约25%的足月单胎妊娠胎盘中也存在，可能是一个胎儿消失的唯一线索。
