Foster R S
Cancer Res. 1978 Mar;38(3):850-8.
Recent studies have demonstrated that systemic Corynebacterium parvum increases serum granulocyte-macrophage colony-stimulating factor and stimulates the proliferation of granulocyte-macrophage progenitor cells. It was hypothesized that more rapid cycling of granulocyte-macrophage progenitor cells would render the cells more sensitive to a cell cycle-specific chemotherapeutic agent. The colony-forming ability of bone marrow granulocyte-macrophage progenitor cells was assayed in vitro with soft agar cultures. C. parvum given before 5-fluorouracil in C57BL/6 mice increased the granulocyte-macrophage progenitor cell toxicity, the lymphopenic effect, and the lethality of 5-fluorouracil. When C. parvum was given after 5-fluorouracil, there was more rapid rebound of granulocyte counts to normal or supranormal levels.
最近的研究表明，全身性微小棒状杆菌可增加血清粒细胞-巨噬细胞集落刺激因子，并刺激粒细胞-巨噬细胞祖细胞的增殖。据推测，粒细胞-巨噬细胞祖细胞更快的循环会使细胞对细胞周期特异性化疗药物更敏感。用软琼脂培养法在体外测定骨髓粒细胞-巨噬细胞祖细胞的集落形成能力。在C57BL/6小鼠中，在给予5-氟尿嘧啶之前给予微小棒状杆菌，可增加粒细胞-巨噬细胞祖细胞毒性、淋巴细胞减少效应以及5-氟尿嘧啶的致死性。当在5-氟尿嘧啶之后给予微小棒状杆菌时，粒细胞计数能更快地反弹至正常或超正常水平。
