Roszkowski K, Nozdryn-Plotnicki B, Roszkowski W, Ko H L, Pulverer G, Jeljaszewicz J
Cancer Immunol Immunother. 1983;15(1):23-6. doi: 10.1007/BF00199457.
Eighty-two patients with metastatic breast cancer were treated with adriamycin, cyclophosphamide, and 5-fluorouracil (FAC). These patients were divided by randomization into two groups. One was receiving cytostatic drugs only, while another received the identical cytostatic medication plus additional therapy consisting of IV infusions of gamma-radiation-sterilized cells of Propionibacterium granulosum strain KP-45. Metastases were localized in six different sites and/or organs. Multiple parameters for monitoring changes in metastatic lesions and laboratory tests were performed serially in all patients. The addition of P. granulosum to standard (FAC) chemotherapy of metastatic breast cancer influenced metastases in the liver. It also resulted in increased survival time within the observation period. Possible mechanisms of immunomodulating activity of P. granulosum in this disease are discussed.
82例转移性乳腺癌患者接受了阿霉素、环磷酰胺和5-氟尿嘧啶（FAC）治疗。这些患者通过随机分组分为两组。一组仅接受细胞毒性药物治疗，而另一组接受相同的细胞毒性药物治疗外加由经γ射线灭菌的颗粒丙酸杆菌KP-45菌株细胞静脉输注组成的额外治疗。转移灶位于6个不同的部位和/或器官。对所有患者连续进行了多项监测转移灶变化的参数和实验室检查。在转移性乳腺癌的标准（FAC）化疗中添加颗粒丙酸杆菌对肝脏转移灶有影响。这也导致了观察期内生存时间的延长。本文讨论了颗粒丙酸杆菌在该疾病中免疫调节活性的可能机制。
