Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, BP 44099, F-31077 Toulouse CEDEX 4, France.
Molecules. 2018 Nov 23;23(12):3066. doi: 10.3390/molecules23123066.
The study of chelating ligands is undoubtedly one of the most significant fields of research in chemistry. The present work is directed to the synthesis of new functionalized derivatives of tripodal C-scorpionate compounds. Tris-2,2,2-(1-pyrazolyl)ethanol, HOCH₂C(pz)₃ (), one of the most important derivatives of hydrotris(pyrazolyl)methane, was used as a building block for the synthesis of new functionalized C-scorpionates, aiming to expand the scope of this unexplored class of compounds. The first dendritic C-scorpionate was successfully prepared and used in the important industrial catalytic reactions, Sonogashira and Heck C-C cross-couplings.
螯合配体的研究无疑是化学领域中最重要的研究领域之一。本工作旨在合成新型功能化三脚 C-冠醚化合物的衍生物。三（2,2,2-（1-吡唑基）乙醇，HOCH₂C（pz）₃（），是三（吡唑基）甲烷的最重要衍生物之一，被用作合成新型功能化 C-冠醚的构建块，旨在扩展这一尚未开发的化合物类别的范围。成功制备了第一个树枝状 C-冠醚，并将其用于重要的工业催化反应，如 Sonogashira 和 Heck C-C 交叉偶联反应。
