Krause Daniela, Jobst Andrea, Langemak Shari Marie, Keeser Daniel, Chrobok Agnieszka I, Langgartner Simon, Adorjan Kristina, Gertzen Markus, Pogarell Oliver, Karch Susanne
1 Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilians University, Munich, Germany.
Clin EEG Neurosci. 2019 May;50(3):154-160. doi: 10.1177/1550059418814987. Epub 2018 Nov 27.
Previous neuroimaging studies have described altered activity in brain areas associated with reward processing following reward or punishment. This study examines the extent to which feedback-based experience of gain and loss is associated with electrophysiological correlates.
Twenty-nine healthy participants used a gambling task that focused on actual nonpredictable gains and losses. During the task, an electroencephalography recording was performed in order to assess reward processing. Event-related potentials were analyzed when participants were receiving gain/loss feedback.
Event-related potentials revealed higher feedback-related negativity for both overall gain and loss compared with a neutral condition in fronto-centro-parietal electrodes. P3 potentials were significantly increased for high gains/losses compared to neutral and small gains/losses.
These results indicate that the paradigm is suitable to evoke specific patterns of reward-related electrophysiological responses. The wavelet analysis showed that electroencephalography frequency variations depended on the amount of gains/losses.
This gambling paradigm is appropriate to measure aspects of feedback processing and could help analyze disease-specific alterations of the reward system in patients.
以往的神经影像学研究描述了在奖励或惩罚后，与奖励处理相关的脑区活动发生改变。本研究考察基于反馈的得失体验与电生理相关性的关联程度。
29名健康参与者使用一项侧重于实际不可预测得失的赌博任务。在任务过程中，进行脑电图记录以评估奖励处理情况。当参与者收到得失反馈时，分析事件相关电位。
事件相关电位显示，与额中央顶叶电极的中性条件相比，总体得失的反馈相关负波更高。与中性和小得失相比，高得失时P3电位显著增加。
这些结果表明该范式适合诱发奖励相关电生理反应的特定模式。小波分析表明，脑电图频率变化取决于得失量。
这种赌博范式适用于测量反馈处理的各个方面，并有助于分析患者奖励系统的疾病特异性改变。
