Vision Science Program, School of Optometry, Infectious Disease and Immunity Program, University of California Berkeley, Berkeley, CA 94720, USA.
Vision Science Program, School of Optometry, Infectious Disease and Immunity Program, University of California Berkeley, Berkeley, CA 94720, USA.
Trends Biochem Sci. 2019 Mar;44(3):214-225. doi: 10.1016/j.tibs.2018.10.007. Epub 2018 Nov 23.
Eicosanoids and specialized proresolving mediators (SPMs) regulate leukocyte function and inflammation. They are ideally positioned at the interface of the innate and adaptive immune responses when lymphocytes interact with leukocytes. Receptors for leukotriene B (LTB), prostaglandin E (PGE), and SPMs are expressed on lymphocytes. Evidence points toward an essential role of these lipid mediators (LMs) in direct regulation of lymphocyte functions. SPMs, which include lipoxins, demonstrate comprehensive protective actions with lymphocytes. LTB and PGE regulation of lymphocytes is diverse and depends on the interaction of lymphocytes with other cells. Importantly, both LTB and PGE are essential regulators of T cell antitumor activity. These LMs are attractive therapeutic targets to control dysregulated innate and adaptive immune responses, promote lymphocyte antitumor activity, and prevent tumor immune evasion.
类二十烷酸和特异性促炎消退介质（SPM）可调节白细胞功能和炎症。当淋巴细胞与白细胞相互作用时，它们处于先天免疫和适应性免疫反应的交汇点，具有理想的位置。白细胞三烯 B（LTB）、前列腺素 E（PGE）和 SPM 的受体在淋巴细胞上表达。有证据表明，这些脂质介质（LMs）在直接调节淋巴细胞功能方面具有重要作用。SPM 包括脂氧素，它们对淋巴细胞具有全面的保护作用。LTB 和 PGE 对淋巴细胞的调节作用多种多样，取决于淋巴细胞与其他细胞的相互作用。重要的是，LTB 和 PGE 都是 T 细胞抗肿瘤活性的重要调节剂。这些 LMs 是控制失调的先天和适应性免疫反应、促进淋巴细胞抗肿瘤活性和防止肿瘤免疫逃逸的有吸引力的治疗靶点。
