靶向脂质介质在癌症生物学中的作用。
Targeting lipid mediators in cancer biology.
机构信息
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
出版信息
Cancer Metastasis Rev. 2018 Sep;37(2-3):557-572. doi: 10.1007/s10555-018-9754-9.
Bioactive lipids are essential components of human cells and tissues. As discussed in this review, the cancer lipidome is diverse and malleable, with the ability to promote or inhibit cancer pathogenesis. Targeting lipids within the tumor and surrounding microenvironment may be a novel therapeutic approach for treating cancer patients. Additionally, the emergence of a novel super-family of lipid mediators termed specialized pro-resolving mediators (SPMs) has revealed a new role for bioactive lipid mediators in the resolution of inflammation in cancer biology. The role of SPMs in cancer holds great promise in our understanding of cancer pathogenesis and can ultimately be used in future cancer diagnostics and therapy.
生物活性脂质是人体细胞和组织的重要组成部分。正如本篇综述所讨论的，肿瘤脂质组具有多样性和可塑性，能够促进或抑制癌症的发生发展。针对肿瘤及其周围微环境中的脂质可能是治疗癌症患者的一种新的治疗方法。此外，一类新型的脂质介质超家族——特异性促炎消退介质（SPM）的出现揭示了生物活性脂质介质在癌症生物学中炎症消退中的新作用。SPM 在癌症中的作用极大地促进了我们对癌症发病机制的理解，并最终可用于未来的癌症诊断和治疗。
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