Center for Integrated Technology and Organic Synthesis, Research Unit MolSys, University of Liège, 4000, Liège (Sart Tilman), Belgium.
Certech, Rue Jules Bordet, Zone Industrielle C, 7180, Seneffe, Belgium.
Top Curr Chem (Cham). 2018 Nov 26;377(1):1. doi: 10.1007/s41061-018-0222-3.
In the current context of transitioning to more sustainable chemical processes, the upgrading of biobased platform molecules (i.e., the chemical transformation of widely available low molecular weight entities from biomass) is attracting significant attention, in particular when combined with enabling continuous flow conditions. The success of this combination is largely due to the ability to explore new process conditions and the perspective of facilitating seamless scalability while maintaining a small overall footprint. This review considers representative continuous flow processes which utilize a selection of currently popular platform molecules that target industrially relevant building blocks, including (a) commodity chemicals, (b) specialty and fine chemicals, and (c) fuels and fuel additives.
在向更可持续的化学工艺转型的当前背景下，生物基平台分子的升级（即通过化学转化将生物质中广泛存在的低分子量物质转化为高附加值产物）引起了人们的极大关注，尤其是当与连续流条件相结合时。这种组合的成功在很大程度上归因于能够探索新的工艺条件，以及在保持小的总体占地面积的同时促进无缝可扩展性的前景。本文综述了利用目前受欢迎的平台分子的一些代表性连续流工艺，这些平台分子的目标是具有工业应用价值的构建块，包括（a）大宗商品化学品，（b）专用化学品和精细化学品，以及（c）燃料和燃料添加剂。
