Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91, Stockholm, Sweden.
Cell Stress Chaperones. 2019 Jan;24(1):7-15. doi: 10.1007/s12192-018-0948-4. Epub 2018 Nov 26.
Hsp70 chaperone systems are very versatile machines present in nearly all living organisms and in nearly all intracellular compartments. They function in many fundamental processes through their facilitation of protein (re)folding, trafficking, remodeling, disaggregation, and degradation. Hsp70 machines are regulated by co-chaperones. J-domain containing proteins (JDPs) are the largest family of Hsp70 co-chaperones and play a determining role functionally specifying and directing Hsp70 functions. Many features of JDPs are not understood; however, a number of JDP experts gathered at a recent CSSI-sponsored workshop in Gdansk (Poland) to discuss various aspects of J-domain protein function, evolution, and structure. In this report, we present the main findings and the consensus reached to help direct future developments in the field of Hsp70 research.
Hsp70 伴侣系统是非常通用的机器，存在于几乎所有的生物体内和几乎所有的细胞内隔室中。它们通过促进蛋白质（再）折叠、运输、重塑、解聚和降解，在许多基本过程中发挥作用。Hsp70 机器受共伴侣的调节。含 J 结构域的蛋白质（JDPs）是 Hsp70 共伴侣中最大的家族，在功能上起着决定作用，指定和指导 Hsp70 的功能。许多 JDP 的特征尚未被理解；然而，一些 JDP 专家在最近在波兰格但斯克举行的由 CSSI 赞助的研讨会上聚集在一起，讨论 J 结构域蛋白功能、进化和结构的各个方面。在本报告中，我们提出了主要的发现和达成的共识，以帮助指导 Hsp70 研究领域的未来发展。
