• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

J 结构域蛋白:从分子机制到疾病。

J-domain proteins: From molecular mechanisms to diseases.

机构信息

Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, Gdansk 80-307, Poland.

Institute of Physics, School of Basic Sciences, École Polytechnique Fédérale de Lausanne - EPFL, Lausanne CH 1015, Switzerland; Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne - EPFL, Lausanne CH 1015, Switzerland.

出版信息

Cell Stress Chaperones. 2024 Feb;29(1):21-33. doi: 10.1016/j.cstres.2023.12.002. Epub 2023 Dec 23.

DOI:10.1016/j.cstres.2023.12.002
PMID:38320449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10939069/
Abstract

J-domain proteins (JDPs) are the largest family of chaperones in most organisms, but much of how they function within the network of other chaperones and protein quality control machineries is still an enigma. Here, we report on the latest findings related to JDP functions presented at a dedicated JDP workshop in Gdansk, Poland. The report does not include all (details) of what was shared and discussed at the meeting, because some of these original data have not yet been accepted for publication elsewhere or represented still preliminary observations at the time.

摘要

J 结构域蛋白(JDPs)是大多数生物体中最大的伴侣蛋白家族,但它们在其他伴侣蛋白和蛋白质质量控制机制网络中的功能仍有许多未解之谜。在这里,我们报告了在波兰格但斯克举行的专门的 JDP 研讨会上介绍的与 JDP 功能相关的最新发现。该报告并未包含会议上分享和讨论的所有(细节)内容,因为其中一些原始数据尚未在其他地方发表,或者当时仍代表初步观察结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaf1/10939069/ee4cf4de9984/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaf1/10939069/ee4cf4de9984/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaf1/10939069/ee4cf4de9984/gr1.jpg

相似文献

1
J-domain proteins: From molecular mechanisms to diseases.J 结构域蛋白:从分子机制到疾病。
Cell Stress Chaperones. 2024 Feb;29(1):21-33. doi: 10.1016/j.cstres.2023.12.002. Epub 2023 Dec 23.
2
The Black Book of Psychotropic Dosing and Monitoring.《精神药物剂量与监测黑皮书》
Psychopharmacol Bull. 2024 Jul 8;54(3):8-59.
3
J-domain protein chaperone circuits in proteostasis and disease.J 结构域蛋白伴侣在蛋白稳态和疾病中的作用。
Trends Cell Biol. 2023 Jan;33(1):30-47. doi: 10.1016/j.tcb.2022.05.004. Epub 2022 Jun 18.
4
"In a State of Flow": A Qualitative Examination of Autistic Adults' Phenomenological Experiences of Task Immersion.“心流状态”:对自闭症成年人任务沉浸现象学体验的质性研究
Autism Adulthood. 2024 Sep 16;6(3):362-373. doi: 10.1089/aut.2023.0032. eCollection 2024 Sep.
5
The quantity, quality and findings of network meta-analyses evaluating the effectiveness of GLP-1 RAs for weight loss: a scoping review.评估胰高血糖素样肽-1受体激动剂(GLP-1 RAs)减肥效果的网状Meta分析的数量、质量及结果:一项范围综述
Health Technol Assess. 2025 Jun 25:1-73. doi: 10.3310/SKHT8119.
6
A rapid and systematic review of the clinical effectiveness and cost-effectiveness of paclitaxel, docetaxel, gemcitabine and vinorelbine in non-small-cell lung cancer.对紫杉醇、多西他赛、吉西他滨和长春瑞滨在非小细胞肺癌中的临床疗效和成本效益进行的快速系统评价。
Health Technol Assess. 2001;5(32):1-195. doi: 10.3310/hta5320.
7
Interventions for promoting habitual exercise in people living with and beyond cancer.促进癌症患者及康复者进行习惯性锻炼的干预措施。
Cochrane Database Syst Rev. 2018 Sep 19;9(9):CD010192. doi: 10.1002/14651858.CD010192.pub3.
8
Antidepressants for pain management in adults with chronic pain: a network meta-analysis.抗抑郁药治疗成人慢性疼痛的疼痛管理:一项网络荟萃分析。
Health Technol Assess. 2024 Oct;28(62):1-155. doi: 10.3310/MKRT2948.
9
Sexual Harassment and Prevention Training性骚扰与预防培训
10
"Just Ask What Support We Need": Autistic Adults' Feedback on Social Skills Training.“只需询问我们需要什么支持”:成年自闭症患者对社交技能培训的反馈
Autism Adulthood. 2025 May 28;7(3):283-292. doi: 10.1089/aut.2023.0136. eCollection 2025 Jun.

引用本文的文献

1
Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice.Dnajc12基因缺陷小鼠的高苯丙氨酸血症和血清素缺乏
Commun Biol. 2024 Dec 18;7(1):1641. doi: 10.1038/s42003-024-07360-6.
2
Unique characteristics of the J-domain proximal regions of Hsp70 cochaperone Apj1 in prion propagation/elimination and its overlap with Sis1 function.热休克蛋白70(Hsp70)辅助伴侣蛋白Apj1的J结构域近端区域在朊病毒传播/消除中的独特特征及其与Sis1功能的重叠。
Front Mol Biosci. 2024 Apr 24;11:1392608. doi: 10.3389/fmolb.2024.1392608. eCollection 2024.
3
The dance of proteostasis and metabolism: Unveiling the caloristatic controlling switch.

本文引用的文献

1
The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria.内质网-表面(ER-SURF)途径利用内质网-线粒体接触位点将蛋白质靶向到线粒体。
EMBO Rep. 2024 Apr;25(4):2071-2096. doi: 10.1038/s44319-024-00113-w. Epub 2024 Apr 2.
2
DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity.DNAJB8 寡聚化是由富含芳香族残基的基序介导的,该基序对于底物活性是可有可无的。
Structure. 2024 Jun 6;32(6):662-678.e8. doi: 10.1016/j.str.2024.02.015. Epub 2024 Mar 19.
3
Analysis of Reconstituted Tripartite Complex Supports Avidity-based Recruitment of Hsp70 by Substrate Bound J-domain Protein.
蛋白质稳态与代谢的共舞:揭开产热控制开关。
Cell Stress Chaperones. 2024 Feb;29(1):175-200. doi: 10.1016/j.cstres.2024.02.002. Epub 2024 Feb 6.
4
Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases.在炎症消退过程中的热休克反应及其在慢性退行性炎症性疾病中的逐渐抑制。
Cell Stress Chaperones. 2024 Feb;29(1):116-142. doi: 10.1016/j.cstres.2024.01.002. Epub 2024 Jan 19.
复性三方复合物分析支持底物结合 J 结构域蛋白通过亲合力募集 Hsp70。
J Mol Biol. 2023 Nov 1;435(21):168283. doi: 10.1016/j.jmb.2023.168283. Epub 2023 Sep 18.
4
identification of modulators of J domain protein-Hsp70 interactions in : a drug repurposing strategy against malaria.疟原虫中J结构域蛋白与热休克蛋白70相互作用调节剂的鉴定:一种抗疟疾的药物重新利用策略
Front Mol Biosci. 2023 Aug 9;10:1158912. doi: 10.3389/fmolb.2023.1158912. eCollection 2023.
5
Backbone and sidechain NMR assignments of residues 1-81 from yeast Sis1 in complex with an Hsp70 C-terminal EEVD peptide.酵母 Sis1 与 Hsp70 C 端 EEVD 肽复合物中残基 1-81 的骨架和侧链 NMR 分配。
Biomol NMR Assign. 2023 Dec;17(2):239-242. doi: 10.1007/s12104-023-10148-0. Epub 2023 Aug 17.
6
Bacterial adaptation to cold: Conservation of a short J-domain co-chaperone and its protein partners in environmental proteobacteria.细菌对低温的适应:环境中变形菌门细菌中一种短J结构域共伴侣蛋白及其蛋白质伙伴的保守性
Environ Microbiol. 2023 Nov;25(11):2447-2464. doi: 10.1111/1462-2920.16478. Epub 2023 Aug 7.
7
Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins.数据驱动的大规模基因组分析揭示了 J 域蛋白中错综复杂的系统发生和功能景观。
Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2218217120. doi: 10.1073/pnas.2218217120. Epub 2023 Jul 31.
8
Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors.内质网中的氧化还原状态直接调节钙通道、肌醇 1,4,5-三磷酸受体的活性。
Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2216857120. doi: 10.1073/pnas.2216857120. Epub 2023 May 22.
9
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP.由人类内质网伴侣蛋白 BiP 的 AMPylation 失调引起的婴儿期发病型糖尿病。
EMBO Mol Med. 2023 Mar 8;15(3):e16491. doi: 10.15252/emmm.202216491. Epub 2023 Jan 27.
10
HSP70-binding motifs function as protein quality control degrons.HSP70 结合基序作为蛋白质质量控制降解基序发挥作用。
Cell Mol Life Sci. 2023 Jan 7;80(1):32. doi: 10.1007/s00018-022-04679-3.