Benfica Camila Zanella, Zanella Teresinha, Farias Lucas Brandolt, Oppermann Maria Lúcia Rocha, Canani Luis Henrique Santos, Lavinsky Daniel
Universidade Federal do Rio Grande do Sul (UFRGS), Cabral 732/1204, Porto Alegre, RS, 90420-121, Brazil.
Department of Ophthalmology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Int Ophthalmol. 2019 Sep;39(9):2069-2076. doi: 10.1007/s10792-018-1043-7. Epub 2018 Nov 26.
To compare choroidal thickness (CT) measurements in preeclamptic and healthy women in the third trimester of pregnancy using optical coherence tomography.
This cross-sectional study included 148 eyes of 74 women, divided into two groups: 27 healthy pregnant women in the third trimester (control group) and 47 age-matched pregnant women in the third trimester with preeclampsia (PE group). Of the 47 subjects in preeclampsia group, 26 were classified as having mild PE and 21 as having severe PE. Choroidal thickness was measured at ten different locations: at the fovea and every 500 µm from the fovea up to 2500 µm temporally and up to 2000 µm nasally.
Comparing CT of both groups, choroid always tended to be thicker in subjects with preeclampsia in comparison with healthy pregnant women, with statistical significance in nasal measures. Dividing PE group according to disease severity, women with severe preeclampsia tended to have thicker choroids in comparison with mild preeclamptic and healthy pregnant women. Choroid was also significantly thicker in preeclamptic patients with serous retinal detachment (SRD) in comparison with preeclamptic patients without SRD (P < 0.01 in all macular points).
Our study showed that choroid tends to be thicker in patients with preeclampsia, with statistical significance only in nasal measures. In patients with SRD, however, choroid is markedly thicker at all points analyzed. From these findings we can hypothesize that preeclampsia can cause a choroidal thickening, which begins in the peripapillary area. As the imbalance increases, the entire choroid becomes thickened.
使用光学相干断层扫描比较妊娠晚期子痫前期和健康孕妇的脉络膜厚度（CT）测量值。
这项横断面研究纳入了74名女性的148只眼，分为两组：27名妊娠晚期健康孕妇（对照组）和47名年龄匹配的妊娠晚期子痫前期孕妇（PE组）。在子痫前期组的47名受试者中，26名被归类为轻度PE，21名被归类为重度PE。在十个不同位置测量脉络膜厚度：在黄斑中心凹以及从黄斑中心凹颞侧每隔500 µm直至2500 µm、鼻侧直至2000 µm处。
比较两组的CT，子痫前期受试者的脉络膜总是比健康孕妇厚，在鼻侧测量中有统计学意义。根据疾病严重程度将PE组分开，重度子痫前期女性的脉络膜比轻度子痫前期和健康孕妇厚。与无浆液性视网膜脱离（SRD）的子痫前期患者相比，有SRD的子痫前期患者的脉络膜也明显更厚（在所有黄斑点P均<0.01）。
我们的研究表明，子痫前期患者的脉络膜往往更厚，仅在鼻侧测量中有统计学意义。然而，在患有SRD的患者中，在所有分析点脉络膜都明显更厚。从这些发现我们可以推测，子痫前期可导致脉络膜增厚，始于视乳头周围区域。随着失衡加剧，整个脉络膜会增厚。
