子痫前期的病理生理学与当前临床管理
Pathophysiology and Current Clinical Management of Preeclampsia.
作者信息
Amaral Lorena M, Wallace Kedra, Owens Michelle, LaMarca Babbette
机构信息
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, USA.
出版信息
Curr Hypertens Rep. 2017 Aug;19(8):61. doi: 10.1007/s11906-017-0757-7.
Abstract
Preeclampsia is characterized by blood pressure greater than 140/90 mmHg in the second half of pregnancy. This disease is a major contributor to preterm and low birth weight babies. The early delivery of the baby, which becomes necessary for maintaining maternal well-being, makes preeclampsia the leading cause for preterm labor and infant mortality and morbidity. Currently, there is no cure for this pregnancy disorder. The current clinical management of PE is hydralazine with labetalol and magnesium sulfate to slow disease progression and prevent maternal seizure, and hopefully prolong the pregnancy. This review will highlight factors implicated in the pathophysiology of preeclampsia and current treatments for the management of this disease.
摘要
子痫前期的特征是妊娠后半期血压高于140/90 mmHg。这种疾病是早产和低出生体重儿的主要原因。为了维持母亲的健康，婴儿提前分娩成为必要，这使得子痫前期成为早产、婴儿死亡率和发病率的主要原因。目前，这种妊娠疾病无法治愈。目前对子痫前期的临床管理是使用肼屈嗪、拉贝洛尔和硫酸镁来减缓疾病进展并预防母亲癫痫发作，希望能延长妊娠期。这篇综述将重点介绍子痫前期病理生理学中涉及的因素以及目前对该疾病的治疗方法。
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