Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Department of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
J Cell Physiol. 2019 Jun;234(6):7781-7787. doi: 10.1002/jcp.27685. Epub 2018 Nov 27.
Diabetic retinopathy is one of the common and serious microvascular complications of diabetes mellitus, as hyperglycemia has metabolic effects on the retina. Hyperglycemia induces increased oxidative stress, which stimulates inflammation pathways and promotes vascular dysfunction of the retina that leads to increased capillary permeability and vascular leakage. One of the main factors involving diabetic retinopathy is the inflammation signaling pathways. In contemporary times, microRNAs (miRNAs) are identified as functional biomarkers for early detection and treatment of numerous diseases specifically diabetic retinopathy. MiRNAs can modulate gene expression through regulation of transcriptional and posttranscriptional of target genes. With that, miRNAs can regulate almost every cellular and developmental process, including the regulation of instinct immune responses and inflammation. The aim of this study is to investigate the role of miRNAs in inflammation pathways and the pathogenesis of diabetic retinopathy.
糖尿病性视网膜病变是糖尿病常见且严重的微血管并发症之一，因为高血糖对视网膜有代谢作用。高血糖会引起氧化应激增加，从而刺激炎症途径，并促进视网膜的血管功能障碍，导致毛细血管通透性和血管渗漏增加。涉及糖尿病性视网膜病变的主要因素之一是炎症信号通路。在现代，microRNAs (miRNAs) 被确定为许多疾病（特别是糖尿病性视网膜病变）的早期检测和治疗的功能性生物标志物。miRNAs 可以通过调节靶基因的转录和转录后调节基因表达。因此，miRNAs 可以调节几乎所有的细胞和发育过程，包括本能免疫反应和炎症的调节。本研究旨在探讨 miRNAs 在炎症途径和糖尿病性视网膜病变发病机制中的作用。
