Department of Orthopaedics, The Ohio State University Wexner Medical Center, 2835 Fred Taylor Dr, Columbus, Ohio, 43202.
J Orthop Res. 2019 Feb;37(2):378-385. doi: 10.1002/jor.24187. Epub 2019 Jan 3.
We sought to determine the relationship between (i) full-thickness cartilage defects and tibiofemoral subchondral surface ratio (SSR) and (ii) disability and quality of life in patients with mild radiographic osteoarthritis (OA) (Kellgren-Lawrence grade 2) or without radiographic OA (Kellgren-Lawrence grades 0 or 1)? A total of 642 participants from the Osteoarthritis Initiative (OAI) with baseline knee MRIs and a Kellgren-Lawrence grade 2 or less on both bilateral screening radiographs were included. The independent relationship was assessed between (i) full-thickness cartilage defect presence and tibiofemoral SSR and (ii) Knee Injury and Osteoarthritis Outcome Score (KOOS) quality of life (QOL), KOOS function in sports and recreation (KOOS-sport/rec), and Western Ontario and McMaster Universities Arthritis Index (WOMAC) disability score after adjustment for relevant confounders with multivariate regression modeling. The prevalence of medial full-thickness defects was 10.4% (67/642) and lateral was 18.1% (116/642). Lateral defect presence was associated with worse KOOS-QOL (beta -3.61 SE 1.04; p = 0.001), KOOS-sport/rec (beta -4.70 SE 1.38; p = 0.001) and WOMAC-disability scores (beta 0.02 SE 0.01; p = 0.001); these associations were not influenced by defect size. A larger medial compartment SSR was associated with worse KOOS-QOL (beta -27.20 SE 6.80; p < 0.001), KOOS-sports/rec (beta -22.30 SE 9.01; p = 0.01) and WOMAC-disability scores (beta 0.16 SE 0.04; p < 0.001). In older adults with little to no radiographic osteoarthritis, lateral full-thickness cartilage defects, irrespective of size, and a larger medial compartment tibiofemoral SSR are potential sources of knee-related symptoms that are not appreciated on standard radiographs. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:378-385, 2019.
我们旨在确定（i）全层软骨缺损与胫骨股骨软骨下表面比（SSR）之间的关系，以及（ii）在轻度放射学骨关节炎（OA）（Kellgren-Lawrence 分级 2）或无放射学 OA（Kellgren-Lawrence 分级 0 或 1）患者中的残疾和生活质量之间的关系？共有 642 名来自骨关节炎倡议（OAI）的参与者在基线膝关节 MRI 检查中纳入，并且双侧筛查射线照相检查的 Kellgren-Lawrence 分级均为 2 级或更低。通过多元回归建模，在调整了相关混杂因素后，评估了（i）全层软骨缺损的存在与胫骨股骨 SSR 之间的独立关系，以及（ii）膝关节损伤和骨关节炎结果评分（KOOS）的生活质量（QOL），KOOS 运动和娱乐功能（KOOS-sport/rec），以及西安大略和麦克马斯特大学关节炎指数（WOMAC）残疾评分。内侧全层缺损的患病率为 10.4%（67/642），外侧为 18.1%（116/642）。外侧缺损的存在与较差的 KOOS-QOL（β-3.61 SE 1.04；p=0.001），KOOS-sport/rec（β-4.70 SE 1.38；p=0.001）和 WOMAC 残疾评分（β0.02 SE 0.01；p=0.001）相关；这些关联不受缺陷大小的影响。较大的内侧间隔 SSR 与较差的 KOOS-QOL（β-27.20 SE 6.80；p<0.001），KOOS-sports/rec（β-22.30 SE 9.01；p=0.01）和 WOMAC 残疾评分（β0.16 SE 0.04；p<0.001）相关。在患有轻度至无放射学骨关节炎的老年患者中，无论大小如何，外侧全层软骨缺损和较大的内侧间隔胫骨股骨 SSR 都是膝关节相关症状的潜在来源，这些症状在标准射线照相中并未被察觉。 © 2018 矫形研究学会。 Wiley Periodicals，Inc. 出版 J 骨科研究 37:378-385，2019 年。
