Lindelöf Bernt, Dal Henrik, Wolk Katarina, Malmborg Niklas
Unit of Dermatology and Venereology, Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
Arch Dermatol. 2005 Apr;141(4):447-51. doi: 10.1001/archderm.141.4.447.
To establish the anatomical site distribution of cutaneous squamous cell carcinoma (SCC) in organ transplant recipients (OTRs) with regard to age and sex.
Retrospective population-based cohort study of OTRs.
Patients who underwent organ transplantation in Sweden from January 1, 1970, to December 31, 1997, registered in the Swedish In-patient Registry and national Swedish Cancer Registry.
From the cohort of 5931 OTRs, we could include 179 patients with 475 cutaneous SCCs. Information on the sites was received from the cancer registry and from the histopathological reports.
The site of each SCC was registered in a computer program displaying the results on a 3-dimensional human figure. The head and neck were the predominant sites in male patients, and the trunk was the predominant site in female patients. The most common site in younger patients (born in 1940 or after) was the chest; and in older patients, the face. The ear was a common site in male patients, but, in contrast, no tumors were located there in female patients. Overall, the OTRs were younger compared with the overall Swedish population with cutaneous SCC.
There are differences in the anatomical site distribution of cutaneous SCCs in OTRs with regard to sex and age, and with regard to the general distribution in Swedish patients. The level of sun exposure is considered the most important factor in explaining those differences, and highlights the importance of sun avoidance in this group of patients.
确定器官移植受者（OTR）中皮肤鳞状细胞癌（SCC）在年龄和性别方面的解剖部位分布。
基于人群的OTR回顾性队列研究。
1970年1月1日至1997年12月31日在瑞典接受器官移植的患者，登记于瑞典住院患者登记处和瑞典国家癌症登记处。
在5931名OTR队列中，我们纳入了179例患有475例皮肤SCC的患者。部位信息来自癌症登记处和组织病理学报告。
每个SCC的部位记录在一个计算机程序中，该程序在三维人体模型上显示结果。男性患者中，头颈部是主要部位；女性患者中，躯干是主要部位。年轻患者（1940年或之后出生）最常见的部位是胸部；老年患者中，面部是最常见部位。耳部是男性患者的常见部位，但女性患者中该部位未发现肿瘤。总体而言，与瑞典皮肤SCC总体人群相比，OTR更年轻。
OTR中皮肤SCC的解剖部位分布在性别、年龄以及与瑞典患者的总体分布方面存在差异。阳光暴露程度被认为是解释这些差异的最重要因素，并凸显了该组患者避免阳光照射的重要性。
