人乳头瘤病毒16型与喉癌的病理特征
Human Papillomavirus Subtype 16 and the Pathologic Characteristics of Laryngeal Cancer.
作者信息
Gomaa Mohammed Abdel Motaal, El Gindy Khalid Elsayed, Nabi Usama Galal Abdel, Mohammed Haitham M, Twab Nisreen A Abdel, Mahmoud Rehab, Mohiy Khalid M
机构信息
Department of Otorhinolaryngology, Minia University, Minia, Egypt.
Department of Pathology, Minia University, Minia, Egypt.
出版信息
OTO Open. 2017 May 8;1(2):2473974X17707925. doi: 10.1177/2473974X17707925. eCollection 2017 Apr-Jun.
OBJECTIVE
Laryngeal cancer is the most common type of cancer in the head and neck. Human papillomavirus (HPV) represents a group of >150 related viruses. Infection with certain types of HPV can cause some types of cancer. This study aimed to evaluate the sociodemographic and histopathologic characters of squamous cell carcinoma of the larynx and its relationship to HPV subtype 16 (HPV-16).
STUDY DESIGN
Cross-sectional.
SETTING
Tertiary university hospitals at 5 districts in Egypt (Minia, Cairo, Giza, Qaluobia, and Bani Seuif).
SUBJECTS AND METHODS
This cross-sectional study was conducted on 50 adult patients with laryngeal cancer who were admitted at 5 tertiary care hospitals in Egypt from January 2014 through December 2014. All patients were subjected to a comprehensive preoperative assessment, histopathologic assessments of tumor biopsies, and immunohistochemical staining for HPV-16.
RESULTS
HPV-16 immunostaining was positive in 9 patients (18%). A significant correlation between HPV-16 immunoreactivity and tumor grade ( < .001) was detected, with no significant correlation between HPV-16 immunoreactivity and other clinical and pathologic variables.
CONCLUSION
The frequency of HPV-16 in laryngeal carcinoma is 18%, and there is significant correlation between HPV-16 and tumor grade.
目的
喉癌是头颈部最常见的癌症类型。人乳头瘤病毒（HPV）是一组超过150种相关病毒。某些类型的HPV感染可导致某些类型的癌症。本研究旨在评估喉鳞状细胞癌的社会人口统计学和组织病理学特征及其与HPV 16型（HPV-16）的关系。
研究设计
横断面研究。
研究地点
埃及5个地区（明亚、开罗、吉萨、盖卢比耶、贝尼苏韦夫）的三级大学医院。
研究对象和方法
本横断面研究对2014年1月至2014年12月在埃及5家三级护理医院收治的50例成年喉癌患者进行。所有患者均接受了全面的术前评估、肿瘤活检的组织病理学评估以及HPV-16免疫组化染色。
结果
9例患者（18%）HPV-16免疫染色呈阳性。检测到HPV-16免疫反应性与肿瘤分级之间存在显著相关性（<0.001），而HPV-16免疫反应性与其他临床和病理变量之间无显著相关性。
结论
喉癌中HPV-16的发生率为18%，且HPV-16与肿瘤分级之间存在显著相关性。
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