阿尔茨海默病中γ-氨基丁酸与工作记忆的关系
The GABA-Working Memory Relationship in Alzheimer's Disease.
作者信息
Mandal Pravat K, Kansara Krity, Dabas Aroma
机构信息
Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Centre, Gurgaon, India.
The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia.
出版信息
J Alzheimers Dis Rep. 2017 Jul 6;1(1):43-45. doi: 10.3233/ADR-170003.
Abstract
Alzheimer's disease (AD) is a highly debilitating neurodegenerative disease with no cure to date. Emerging evidence indicates aberrations of the primary inhibitory neurotransmitter GABA in the frontal, parietal and temporal cortices, and hippocampal regions of the AD brains. GABA levels have been reported to predict working memory (WM) load capacity in the healthy young population. Since working memory is impaired in AD, it opens an active area of research to investigate the influence of GABA on WM performance in AD. Advancements in neuroimaging techniques and signal processing tools can aid in neurochemical profiling of GABA in AD as well as facilitate in probing the role of GABA in AD-specific impairments of working memory.
摘要
阿尔茨海默病（AD）是一种极具致残性的神经退行性疾病，迄今为止尚无治愈方法。新出现的证据表明，AD患者大脑的额叶、顶叶和颞叶皮质以及海马区中主要抑制性神经递质γ-氨基丁酸（GABA）存在异常。据报道，GABA水平可预测健康年轻人群的工作记忆（WM）负荷能力。由于AD患者的工作记忆受损，因此开展了一个活跃的研究领域，以调查GABA对AD患者WM表现的影响。神经成像技术和信号处理工具的进步有助于对AD患者的GABA进行神经化学分析，并有助于探究GABA在AD特异性工作记忆损伤中的作用。
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