使用MEGA-PRESS进行GABA定量分析：区域和半球差异。
GABA quantitation using MEGA-PRESS: Regional and hemispheric differences.
作者信息
Grewal Monika, Dabas Aroma, Saharan Sumiti, Barker Peter B, Edden Richard A E, Mandal Pravat K
机构信息
Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Centre, Gurgaon, India.
The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, Maryland, USA.
出版信息
J Magn Reson Imaging. 2016 Dec;44(6):1619-1623. doi: 10.1002/jmri.25324. Epub 2016 Jun 5.
PURPOSE
To measure in vivo brain gamma-aminobutyric acid (GABA) concentrations, and assess regional and hemispheric differences, using MR spectroscopy ( H-MRS).
MATERIALS AND METHODS
GABA concentrations were measured bilaterally in the frontal cortex (FC), parietal cortex (PC), and occipital cortex (OC) of 21 healthy young subjects (age range 20-29 years) using 3 Tesla Philips scanner. A univariate general linear model analysis was carried out to assess the effect of region and hemisphere as well as their interaction on GABA concentrations while controlling for sex and gray matter differences.
RESULTS
Results indicated a significant regional dependence of GABA levels [F(2,89) = 11.725, P < 0.001, ηp2 = .209] with lower concentrations in the FC compared with both PC (P < 0.001) and OC (P < 0.001) regions. There was no significant hemispheric differences in GABA levels [F(1,89) = .172; P = 0.679; ηp2 = .002].
CONCLUSION
This study reports the concentrations of GABA in the FC, PC, and OC brain regions of healthy young adults. GABA distribution exhibits hemispheric symmetry, but varies across regions; GABA levels in the FC are lower than those in the PC and OC. J. Magn. Reson. Imaging 2016;44:1619-1623.
目的
使用磁共振波谱（¹H-MRS）测量活体脑内γ-氨基丁酸（GABA）浓度，并评估区域和半球差异。
材料与方法
使用3特斯拉飞利浦扫描仪对21名健康年轻受试者（年龄范围20 - 29岁）的双侧额叶皮质（FC）、顶叶皮质（PC）和枕叶皮质（OC）进行GABA浓度测量。进行单变量一般线性模型分析，以评估区域和半球的影响以及它们在控制性别和灰质差异时对GABA浓度的相互作用。
结果
结果表明GABA水平存在显著的区域依赖性[F(2,89) = 11.725，P < 0.001，ηp² = 0.209]，与PC（P < 0.001）和OC（P < 0.001）区域相比，FC中的浓度较低。GABA水平没有显著的半球差异[F(1,89) = 0.172；P = 0.679；ηp² = 0.002]。
结论
本研究报告了健康年轻成年人FC、PC和OC脑区的GABA浓度。GABA分布呈现半球对称性，但因区域而异；FC中的GABA水平低于PC和OC中的水平。《磁共振成像杂志》2016年；44:1619 - 1623。
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