Plasma renin activity and electrolyte and water metabolism in normal and in genetically hypertensive (Okamoto) Wistar rats.

The electrolyte and water metabolisms and plasma renin activity (PRA) were investigated in genetically hypertensive (Okamoto) and in normotensive Wistar rats. The water intake, PRA, urine volume, urinary Na excretion and Na/K ratio were all found to be smaller in the genetically hypertensive rats than in the controls. No relationship could be demonstrated between PRA values and water intake.